What Is Hereditary Cancer Screening?
Hereditary cancer genetic testing analyzes your DNA for mutations in genes that increase cancer risk. These mutations are inherited from a parent and can significantly raise the lifetime risk of developing breast, ovarian, colorectal, pancreatic, prostate, melanoma, and other cancers. Knowing your status lets you take preventive action before cancer develops.
9 Genes
BRCA1, BRCA2, PALB2, TP53, PTEN, CDH1, STK11, ATM, CHEK2
5 Genes
BRCA1, BRCA2, Lynch genes, RAD51C, RAD51D
7 Genes
MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH
5 Genes
BRCA2, PALB2, ATM, CDKN2A, STK11
5 Genes
BRCA2, BRCA1, HOXB13, ATM, CHEK2
5 Genes
CDKN2A, CDK4, BAP1, MC1R, MITF
Plus 92 additional genes covering rare and moderate-risk cancer syndromes — every gene in the panel is selected per NCCN, ACMG, and major cancer genetics society guidance.
Do You Meet NCCN Criteria for Testing?
[ Select Any That Apply ]The National Comprehensive Cancer Network (NCCN) publishes guidelines that most insurance companies follow when deciding whether to cover hereditary cancer testing. If any of these apply to you, your test is likely covered.
Based on NCCN eligibility criteria. Select any that apply to you.
| CPT Code | Used For |
|---|---|
| 81432 | BRCA1/BRCA2 full gene sequence analysis |
| 81433 | BRCA1/BRCA2 deletion/duplication analysis |
| 81435 | Hereditary colon cancer disorders (e.g., Lynch syndrome) — MLH1, MSH2, MSH6, PMS2, EPCAM |
| 81479 | Unlisted molecular pathology procedure — multi-gene panels |
We handle pre-authorization, verify your benefits, and provide a superbill if you need to submit for reimbursement.
What Happens If You Test Positive?
[ A Plan, Not Just a Result ]A positive result means you carry a pathogenic variant that increases your cancer risk. You will receive a personalized screening and prevention plan based on NCCN guidelines — and a board-certified genetic counselor walks you through every step.
Enhanced Screening
Earlier and more frequent screening — mammograms, MRIs, colonoscopies — scheduled around your specific variant.
Medications
Risk-reducing medications like tamoxifen or aspirin, discussed with your care team where appropriate.
Surgical Consult
In high-risk cases, a discussion of prophylactic surgery — always your choice, always with expert guidance.
“My dad and his brother both died of colon cancer before age 55. I was 46 when I finally did the test. They found an MLH1 mutation — Lynch Syndrome. My gastroenterologist immediately scheduled a colonoscopy. They removed three pre-cancerous polyps that were already there. Without that test, I might have waited until symptoms showed up.”
Gene Matrix patient · MLH1 (Lynch syndrome) detected
Why Not Wait for a Hospital Referral?
Hospital genetics departments can mean weeks of waiting for a counseling slot before a test is even ordered. Gene Matrix delivers the same laboratory quality hospitals use — made simple, accessible, and actionable — with results in 5–7 days, faster than most hospital genetics departments, and a board-certified genetic counselor included with every positive result.
What Hereditary Cancer Screening Costs
[ No Per-Test Fees. No Surprises. ]One-time purchase — the full 108-gene panel with genetic counseling and an NCCN-aligned screening roadmap.
The Hereditary Cancer Panel is included with your Gene Matrix Membership — along with all 10 other genetic tests. No per-test fees. No surprises.
Start Membership — $89/moMany insurance plans cover genetic testing for individuals who meet NCCN criteria, using CPT codes 81432, 81433, 81435, and 81479. We verify your coverage before you order. HSA/FSA eligible. See the full cost breakdown →
Hereditary Cancer Screening FAQs
[ Answered By Experts ]Knowledge Saves Lives.
Hereditary cancers are highly preventable when you know your risk. The 108-gene panel gives you and your doctor the information needed to build a personalized prevention strategy.