What’s Analyzed
[ 150+ Genes · 6 Areas ]GenePain examines 150+ genes across 6 areas of your pain biology — 6 answers that only your DNA can give.
How You Feel Pain
Your DNA literally sets the volume dial on your pain signals. Certain gene variants amplify what your nerves send to your brain — the same injury can feel twice as intense.
How Your Body Handles Pain Meds
CYP2D6, CYP3A4, and ABCB1 determine whether analgesics work for you — or never reach therapeutic levels at all.
Your Inflammation Profile
IL6, TNF-alpha, and COX2 variants reveal inherited inflammatory set points behind chronic pain.
How Well Pain Relievers Work For You
COX2 gene variants explain why some people have extreme NSAID sensitivity while others can take ibuprofen without effect.
Your Nerve Health
TRPV1 and SCN9A variants can make nerve endings significantly more sensitive to heat and pain signals.
How Fast You Heal
Variants like GCH1 reduce your natural pain gating — shaping how you recover from injury, surgery, or training.
Your pain experience has a genetic explanation
[ Key Genes + Answers ]“Why do I feel pain so much more intensely than other people?”
[ What the science says ]The SCN9A gene encodes a sodium channel that determines how strongly pain signals travel to your brain. Variants in COMT affect how quickly your brain degrades pain-signal neurotransmitters. People with certain COMT variants experience significantly higher pain intensity from the same stimulus as others — this isn’t psychological. OPRM1 controls how your natural pain receptors respond, affecting your baseline pain sensitivity.
GenePain tests 28 pain sensitivity genes including SCN9A, COMT, and OPRM1 — giving you (and your doctor) objective genetic evidence for your pain experience and a basis for a completely different treatment approach.
“Why don’t pain medications seem to work for me?”
[ What the science says ]CYP2D6 is the enzyme that converts codeine into morphine — without it, codeine does nothing. About 7-10% of people are poor CYP2D6 metabolizers, making codeine completely ineffective. Conversely, ultra-rapid metabolizers convert it so fast they can reach dangerous levels on normal doses. CYP3A4 affects oxycodone, fentanyl, and many other pain drugs. ABCB1 controls how drugs cross the blood-brain barrier.
GenePain maps your complete analgesic and NSAID pharmacogenomics profile across 40+ pain medications — telling your pain specialist exactly which drugs work with your biology and which ones are wasting your time.
“Is my chronic inflammation genetic — or am I doing something wrong?”
[ What the science says ]Interleukin-6 (IL6) is a key inflammatory cytokine — gene variants that cause overproduction result in chronic systemic inflammation even without an injury or infection. TNF-alpha variants similarly drive persistent immune activation. COX2 gene variants explain why some people have extreme NSAID sensitivity while others can take ibuprofen without effect. These aren’t lifestyle failures — they’re inherited inflammatory set points.
GenePain identifies your inflammation genetics across 25 key genes — helping your rheumatologist distinguish between lifestyle-driven and genetic-driven inflammation to target treatment precisely.
How It Works
[ From Swab To Answers ]Your pain genetics kit ships free
A lab-grade collection kit arrives at your home in 2-3 business days. Inside is a simple saliva collection tube, clear instructions, and a prepaid return envelope. No needles. No lab visit. No appointment required.
Collect your sample at home
A simple saliva sample is all we need. Spit into the tube, cap it, seal the prepaid return envelope, and drop it in any mailbox. The whole process takes under two minutes.
We sequence 150+ pain genes
Your sample is processed in our CLIA-certified lab using next-generation sequencing. We analyze every key gene related to your pain sensitivity, analgesic response, inflammation pathways, NSAID metabolism, and nerve function. Board-certified geneticists review your results.
Your personalized pain profile
In 5-7 days, your comprehensive GenePain report is ready. Share it with your pain specialist, anesthesiologist, or primary care doctor — it maps your medication compatibility, pain sensitivity profile, inflammation risk, and personalized management plan.
What’s in your report
- Pain sensitivity score & threshold profile
- Medication compatibility across 40+ analgesics
- NSAID & opioid pharmacogenomics
- Inflammation risk markers
- Nutrition plan — 14 dietary recommendations
- Exercise protocol + 6 ranked supplements
Included With Your Membership
[ GenePain + 10 More Tests ]GenePain is included with your Gene Matrix Membership — along with all 10 other genetic tests. No per-test fees. No surprises.
A standalone panel at typical lab pricing — a separate order, a separate kit, and a report that never updates.
This test individually: $329. With your membership: included at $89/mo (or $59/mo billed annually) along with all 10 other tests.
No per-test fees. No surprises. 30-day guarantee. HSA/FSA eligible.
The gene that finally explained their pain
[ Verified Results ]“I had chronic back pain for 8 years and tried every medication. GenePain showed I’m a CYP2D6 ultra-rapid metabolizer — pain medications were clearing my system too fast to work. My pain specialist switched my treatment and I finally have relief.”
Sandra L. — Phoenix, AZ · CYP2D6 ultra-rapid metabolizer identified