What’s Analyzed
[ 724+ Medications · 10 Specialties ]With 724+ medications across 10 specialties, explore how your genes affect the drugs you already take — or may need in the future.
Heart & Blood Pressure
Blood thinners, statins, and blood pressure medications vary dramatically based on your genes. Your DNA can determine if warfarin gives you too much or too little protection — or if a common statin could cause muscle damage.
Mental Health
Your genes predict how you respond to antidepressants. CYP2D6 affects fluoxetine, paroxetine, and venlafaxine; CYP2C19 affects citalopram, escitalopram, and sertraline.
Pain Relief
Codeine, tramadol, and opioids affect people very differently — and genetics explain why. Some convert codeine at 10x the normal rate; others barely convert it at all.
Cancer Therapy
Pre-chemotherapy medication optimization — know how your body processes cancer treatments before the first dose.
Stomach & Digestion
Stomach and acid medications processed through your liver’s enzyme pathways — dosing that fits your metabolism, not the average patient.
Diabetes & Hormones
Diabetes medications and hormone therapies guided by your metabolic genetics — one of 10 specialties in your report.
Your genes explain why medications feel wrong
[ Key Genes + Answers ]“My antidepressant stopped working. Why?”
[ What’s really happening ]If you carry certain variations in your CYP2D6 gene, your liver may break down antidepressants too fast — meaning they leave your body before they can work. Or too slow — meaning they build up and cause side effects.
GenePGx identifies your exact CYP2D6 type so your doctor can choose an antidepressant that actually reaches effective levels in your bloodstream.
“This pain medication makes me feel awful. Is that normal?”
[ What’s really happening ]Some people convert codeine or tramadol at 10x the normal rate. This floods your system with active drug all at once — causing nausea, dizziness, or even dangerous reactions. Others barely convert it at all, getting zero pain relief.
GenePGx shows exactly how your body converts pain medications, so your doctor can prescribe alternatives that give you effective relief without the misery.
“My blood thinner dose keeps changing. Why can’t they get it right?”
[ What’s really happening ]Two genes — CYP2C9 and VKORC1 — control how fast your body breaks down warfarin AND how sensitive you are to it. Get either one wrong and you’re either clotting or bleeding. Doctors often spend months adjusting doses through trial and error.
GenePGx calculates your optimal warfarin starting dose before you take your first pill — the same approach used by major hospital systems and the FDA.
How It Works
[ From Swab To Answers ]Your kit arrives at your door
A sleek, lab-ready DNA collection kit shipped directly to you. Everything you need is inside — collection swab, instructions, pre-paid return envelope.
A 90-second cheek swab at home
No needles. No lab visits. Gently swab the inside of your cheek for 30 seconds each side. Cap the tube, seal the envelope, drop it in any mailbox.
CLIA-certified lab analyzes 98+ genes
Your sample goes to our CLIA-certified, CAP-accredited laboratory. We sequence every drug metabolism gene — CYP2D6, CYP2C19, CYP2C9, VKORC1, SLCO1B1 and 90+ more — with 99.9% accuracy.
Your personalized report is ready
In 5-7 days, you receive a detailed, easy-to-read report showing exactly how your body processes each medication class. Share it with any doctor, pharmacist, or specialist — it’s yours forever.
What’s in your report
- Metabolizer status summary — CYP2D6, CYP2C19, CYP2C9 & more
- Personalized medication guide across 700+ drugs
- Cardiovascular, psychiatric, pain & oncology sections
- CPIC and DPWG guideline references for prescribers
- Aligned with FDA pharmacogenomic drug labels
- Ready to share with any provider — yours for life
Included With Your Membership
[ GenePGx + 10 More Tests ]GenePGx is included with your Gene Matrix Membership — along with all 10 other genetic tests. No per-test fees. No surprises.
A standalone panel at typical lab pricing — a separate order, a separate kit, and a report that never updates.
This test individually: $299. With your membership: included at $89/mo (or $59/mo billed annually) along with all 10 other tests.
No per-test fees. No surprises. 30-day guarantee. HSA/FSA eligible.
The gene that changed their treatment
[ Verified Results ]“I had been on antidepressants for 3 years with no improvement. GenePGx revealed I’m a poor CYP2D6 metabolizer — my body couldn’t process the drug. My psychiatrist switched my medication and within 6 weeks I felt like myself again.”
Marcus T. — Houston, TX · CYP2D6 poor metabolizer identified
“My cardiologist adjusted my warfarin dose five times in three months. My INR was never in range — I was always either too high (bleeding risk) or too low (clot risk). Turns out I carry two gene variants that together make me extremely sensitive to warfarin. My therapeutic dose is actually less than half of what most people need.”
Stable INR for 14 months straight · Warfarin sensitivity identified
Frequently asked
GenePGx analyzes 98+ genes that affect how your body metabolizes and responds to 700+ medications. These genetic variations can make certain drugs more or less effective, or increase the risk of side effects. By understanding your genetic profile, doctors can prescribe medications that are more likely to work for you at the right dose.
GenePGx covers 700+ commonly prescribed medications across 10 medical specialties including cardiovascular drugs, psychiatric medications, pain relievers, cancer treatments, antibiotics, diabetes medications, and more. The test analyzes genes that affect drug metabolism, efficacy, and side effect risk.
Yes! GenePGx provides lifelong information about how your body processes medications. Having this information before you need it allows your doctor to make informed prescribing decisions immediately when medications are needed, potentially avoiding adverse reactions or ineffective treatments.
Absolutely! If you’re experiencing side effects or your medications are not providing adequate relief, GenePGx can help explain why. Your genetic profile may reveal that you are a poor metabolizer of certain drugs, requiring different medications or dosage adjustments.
Yes! Pharmacogenomic testing is increasingly recognized by healthcare providers and is supported by FDA guidelines and clinical practice recommendations. Our reports are designed for clinical use and include specific prescribing recommendations with CPIC and DPWG guideline references.
GenePGx focuses specifically on drug-gene interactions and medication response. With 700+ medications covered across 10 specialties, it’s one of the most comprehensive PGx panels available. Our test is clinically actionable - the results directly inform medication selection and dosing decisions.