[ Clinical Guides · Cancer · Medications · Nutrition ]

Clinical Guides — Deep Answers for Hard Questions

Long-form, medically reviewed guides that go further than a landing page can: what to do after a positive BRCA result, how Lynch syndrome surveillance actually works, why your diet keeps failing, and what the published pharmacogenomics evidence really says. Every guide is written by our clinical team and reviewed by our lab director.

Written by the Gene Matrix clinical teamMedically reviewed by Shawn Desai, MD, PhDAugust 2026
[ 8 In-Depth Guides ][ Medically Reviewed ][ No Referral Needed ]

Hereditary Cancer Risk

[ Cluster A · 5 Guides ]
Next Steps

After a Positive BRCA Result: What Happens Next

NCCN-aligned next steps after a positive BRCA1/BRCA2 result — enhanced MRI + mammogram screening from 25, ovarian surveillance, risk-reducing options, and family cascade testing.

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Access

Hereditary Cancer Testing Without a Referral

How direct-to-consumer hereditary cancer testing works, when insurance still applies under NCCN criteria, and exactly what our no-referral process looks like.

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Comparison

At-Home vs Clinical Cancer Genetic Testing

An honest comparison of at-home cheek-swab panels and hospital genetics — wait times, cost, and the situations where the clinical route is genuinely better.

Read the guide →
Syndrome Guide

Lynch Syndrome: Genes, Risks & Surveillance

MLH1, MSH2, MSH6, PMS2, and EPCAM explained — up to 80% lifetime colorectal risk, the colonoscopy surveillance schedule, and why 1 in 279 people carry it.

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Risk Guide

Ovarian, Colon & Pancreatic Cancer Genetics

Hereditary risk by cancer type — ovarian ~1.3% to 44%, colorectal ~4% to 80%, pancreatic ~1.6% to 10% — and the genes behind each.

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Medications & Pharmacogenomics

[ PGx Cluster ]
Research Report

The State of Pharmacogenomics 2026

A synthesis of published research: up to 99% of people carry an actionable PGx variant, 40% fail their first antidepressant, and what CPIC/FDA guidance now covers.

Read the report →
Reference

Gene & Term Glossary

Plain-English definitions of 18 essential genetics terms — from BRCA1 and CYP2D6 to metabolizer types and CLIA/CAP certification.

Browse the glossary →
Landing

Medication DNA Test

How a drug-response genetic test finds the right medication and dose for your DNA across 700+ medications.

Visit the page →

Nutrition & Weight

[ Cluster E ]
Weight

DNA and Weight Management

FTO, MC4R, and ADIPOQ — why diets fail at the genetic level and what a DNA-matched strategy actually changes.

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Nutrition 101

Nutrigenomics Basics

How genes shape nutrient processing — lactose (LCT), caffeine (CYP1A2), vitamin D (VDR/GC), and folate (MTHFR) — explained simply.

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Every Guide Leads Somewhere Actionable

[ 11 Tests · One Membership ]

Each guide ends in a next step, not a sales pitch. When you're ready, all 11 Gene Matrix tests — hereditary cancer, pharmacogenomics, nutrition, and more — are included in one membership at $89/month ($59/mo billed annually, $712/yr). CLIA-certified lab, results in 5–7 days (48-hour priority available), 30-day money-back guarantee.

[ Clinically Reviewed ][ CPIC · NCCN · ACMG Referenced ][ Updated Quarterly ]