Your Genes Explain Why Medications Feel Wrong
CYP2D6 & SSRIs
If you carry certain variations in your CYP2D6 gene, your liver may break down antidepressants too fast — meaning they leave your body before they can work. Or too slow — meaning they build up and cause side effects. A medication DNA test identifies your exact CYP2D6 type so your doctor can choose an antidepressant that actually reaches effective levels in your bloodstream.
Codeine & Tramadol
Some people convert codeine or tramadol at 10x the normal rate — flooding the system with active drug all at once, causing nausea, dizziness, or even dangerous reactions. Others barely convert it at all, getting zero pain relief. Your report shows exactly how your body converts pain medications.
Warfarin Dosing
Two genes — CYP2C9 and VKORC1 — control how fast your body breaks down warfarin AND how sensitive you are to it. Get either one wrong and you’re either clotting or bleeding. The test calculates your optimal starting dose before your first pill — the same approach used by major hospital systems and the FDA.
These aren’t edge cases. They’re everyday situations affecting millions of people — 1 in 3 people carry a variant that changes how they process warfarin.
The Gene That Changed Their Treatment
[ Real People. Real Medications. ]“I spent 8 years on four different antidepressants. Some did nothing, some made me gain 30 pounds, one gave me heart palpitations. Every doctor said ‘let’s try something else.’ After the test, we discovered I’m a CYP2D6 poor metabolizer — I actually can’t process most SSRIs properly. My psychiatrist switched me to a medication that bypasses that enzyme entirely.”
Antidepressants · CYP2D6 poor metabolizer — “First time in 8 years I feel like myself.”
“My cardiologist adjusted my warfarin dose five times in three months. My INR was never in range — I was always either too high (bleeding risk) or too low (clot risk). Turns out I carry two gene variants that together make me extremely sensitive to warfarin. My therapeutic dose is actually less than half of what most people need.”
Warfarin · CYP2C9 + VKORC1 variants — “Stable INR for 14 months straight.”
“After my minor heart procedure, I was put on clopidogrel to prevent clots. A follow-up test six months later saw basically no drug effect at all. The result revealed I’m an ultra-rapid CYP2C19 metabolizer — my body processes the drug so fast it never accumulates to therapeutic levels.”
Clopidogrel · Ultra-rapid CYP2C19 metabolizer — “Switched to prasugrel. Therapy now working.”
700+ Medications Covered
[ Across 10 Medical Specialties ]If you take it, there is a good chance we can tell you how your genes affect it — including the drugs you already take and the ones you may need in the future.
Blood thinners, statins, beta-blockers, and blood pressure medications — including warfarin sensitivity and statin muscle-damage risk.
Antidepressants, antipsychotics, mood stabilizers, ADHD medications, and anxiolytics.
Opioids, NSAIDs, muscle relaxants, migraine medications, and local anesthetics.
Chemotherapy agents, targeted therapies, immunotherapy, and supportive care.
Proton pump inhibitors and gastroenterology medications.
Endocrinology and metabolic medications, plus transplant and immunosuppressants.
What’s Your Metabolizer Type?
For every drug your body processes, you fall into a metabolizer type. Poor metabolizers can’t process a drug properly — it builds up to toxic levels or never activates at all. Intermediate metabolizers process it more slowly than average. Normal metabolizers respond as expected. Ultrarapid metabolizers clear the drug so fast it never reaches therapeutic levels. One test maps your type across 700+ medications — for life.
What a Medication DNA Test Costs
[ One Test. Lifetime Value. ]One-time purchase — your full drug-response profile across 700+ medications, yours forever.
GenePGx is included with your Gene Matrix Membership — along with all 10 other genetic tests. No per-test fees. No surprises.
Start Membership — $89/moYour DNA never changes. Share your report with any provider, anywhere, anytime — no repeat tests needed. Covered by many insurance plans. HSA/FSA eligible. See the full cost breakdown →
Medication DNA Test FAQs
[ Everything You Need To Know ]Stop Guessing. Start Knowing.
Your genes don’t change. One test gives your doctor the information they need to prescribe confidently — today and every year of your life.