[ 108 Genes · 15+ Cancer Types ]

Hereditary Cancer Genetic Testing

Know your risk for 15+ hereditary cancers before symptoms ever appear. Our 108-gene panel analyzes BRCA1, BRCA2, Lynch syndrome, TP53, PALB2, and 95+ more. Results in 5–7 days with genetic counseling.

Order Your Test See Cancers Covered
[ 108-Gene Panel ][ BRCA1/2 · Lynch · TP53 · PALB2 ][ 5–7 Day Results ][ Counseling Included ]

Every Major Hereditary Cancer, Covered

Cancer cells detected through hereditary cancer genetic testing
Up to 72% lifetime risk with a BRCA1 mutation (vs. 12.5% average)

Breast Cancer

Genes: BRCA1, BRCA2, PALB2, TP53, PTEN, CDH1, STK11, ATM, CHEK2

Up to 44% lifetime risk with a BRCA1 mutation

Ovarian Cancer

Genes: BRCA1, BRCA2, Lynch genes, RAD51C, RAD51D

Up to 80% lifetime risk with Lynch Syndrome

Colorectal Cancer

Genes: MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH

Family-history driven — panel covers all major susceptibility genes

Pancreatic Cancer

Genes: BRCA2, PALB2, ATM, CDKN2A, STK11

Up to 27% risk by age 80 for men with BRCA2 mutations

Prostate Cancer

Genes: BRCA2, BRCA1, HOXB13, ATM, CHEK2

Hereditary melanoma genes screened across the full panel

Melanoma Cancer

Genes: CDKN2A, CDK4, BAP1, MC1R, MITF

Do You Meet NCCN Criteria for Testing?

[ Insurance Likely Covers It ]

The National Comprehensive Cancer Network (NCCN) publishes guidelines that most insurance companies follow when deciding whether to cover hereditary cancer testing. If any of these apply to you, your test is likely covered.

1. Personal history of breast, ovarian, colorectal, endometrial, or pancreatic cancer diagnosed ≤50 years old

2. Family history of BRCA-related cancer in first- or second-degree relative

3. Known pathogenic variant in BRCA1, BRCA2, or Lynch syndrome gene in family

4. Multiple primary cancers in the same individual

5. Triple-negative breast cancer at any age

6. Male breast cancer or metastatic prostate cancer

7. Ovarian cancer (epithelial) at any age

8. ≥10 adenomatous colorectal polyps or ≥2 hamartomatous polyps

Personal/family history meets NCCN criteria · Ashkenazi Jewish ancestry with family history · Personal history of ovarian, male breast, or pancreatic cancer · ≥2 breast cancer primaries in same individual — our team checks your insurance

Insurance Billing Codes

[ Pre-Authorization Handled For You ]
CPT CodeUsed For
81432Hereditary breast cancer-related disorders — full gene sequence analysis (BRCA1/BRCA2)
81433Hereditary breast cancer-related disorders — duplication/deletion analysis
81435Hereditary colon cancer disorders (e.g., Lynch syndrome) — 5-50 genes
81479Unlisted molecular pathology procedure — extended multi-gene panels

We handle pre-authorization, verify your benefits, and provide a superbill if you need to submit for reimbursement.

How Hereditary Cancer Testing Works

[ From Swab To Screening Plan ]
[ 01 ]

Order Online

Start your membership — $89/month. We ship your kit within 24 hours.

[ 02 ]

Collect at Home

Swab both cheeks for 30 seconds. No blood, no needles. Mail back prepaid.

[ 03 ]

Lab Analysis

Our CLIA lab sequences 108 cancer genes using NGS. Results in 5–7 days.

[ 04 ]

Review & Plan

View your report. If positive, get a free genetic counseling session and screening plan.

View the 108-gene panel sample report (PDF) ↓

Key Genes in the Panel

[ NCCN · ACMG Aligned ]
GeneLocusAssociated Cancers
BRCA117q21.31Breast, ovarian, prostate, pancreatic
BRCA213q13.1Breast, ovarian, prostate, pancreatic
PALB216p12.2Breast, pancreatic
TP5317p13.1Breast, sarcoma, brain, adrenal (Li-Fraumeni)
PTEN10q23.31Breast, thyroid, endometrial (Cowden)
CDH116q22.1Gastric, lobular breast
STK1119p13.3Colorectal, breast, pancreatic (Peutz-Jeghers)
CDKN2A9p21.3Melanoma, pancreatic
ATM11q22.3Breast, colorectal, prostate
CHEK222q12.1Breast, colorectal, prostate
MLH13p22.2Colorectal, endometrial (Lynch)
MSH22p21-p16.3Colorectal, endometrial (Lynch)
MSH62p16.3Colorectal, endometrial (Lynch)
PMS27p22.1Colorectal, endometrial (Lynch)
EPCAM2p21Colorectal (Lynch)
APC5q22.2Colorectal (FAP/AFAP)
MUTYH1p34.1Colorectal
HOXB1317q21.32Prostate
RAD51C17q22Ovarian
RAD51D17q12Ovarian
BAP1Panel geneMesothelioma, melanoma, renal
NBN8q21.3Cancer susceptibility (panel gene)
BRIP117q23.2Cancer susceptibility (panel gene)
BARD12q35Cancer susceptibility (panel gene)

+ 92 additional genes covering rare and moderate-risk cancer syndromes — the most clinically significant cancer susceptibility genes identified by NCCN, ACMG, and major cancer genetics societies.

Get the Panel with Your Membership

[ No Per-Test Fees. No Surprises. ]
Hereditary Cancer Panel individually $499

One-time purchase — a single test, a single report.

Gene Matrix Membership — all 11 tests $89/mo

Hereditary Cancer Panel is included with your Gene Matrix Membership — along with all 10 other genetic tests. No per-test fees. No surprises.

Start Membership — $89/mo

This test individually: $499. With your membership: included at $89/mo (or $59/mo billed annually) along with all 10 other tests. Compare all 11 tests

Frequently Asked Questions

[ Hereditary Cancer, Answered ]

“My mother had breast cancer at 42. I finally got tested and found out I carry a BRCA2 variant. My doctor immediately put me on an enhanced screening protocol. That test may have saved my life.”

Jennifer K. — Chicago, IL · BRCA2 pathogenic variant detected
Hereditary cancer genetic testing analyzes your DNA for mutations in genes that increase cancer risk. These mutations are inherited from a parent and can significantly raise the lifetime risk of developing breast, ovarian, colorectal, pancreatic, prostate, melanoma, and other cancers. Knowing your status lets you take preventive action before cancer develops.
Our hereditary cancer panel analyzes 108 genes associated with hereditary cancer syndromes. This includes BRCA1 and BRCA2 (breast/ovarian), Lynch syndrome genes (colorectal/endometrial), TP53 (Li-Fraumeni), PTEN (Cowden), APC (FAP), CDH1 (gastric), STK11 (Peutz-Jeghers), PALB2, CHEK2, ATM, and over 95 additional cancer susceptibility genes.
The panel screens for risk across 15+ cancer types including breast, ovarian, colorectal, endometrial, pancreatic, prostate, gastric, melanoma, thyroid, renal, and others. Each gene in the panel is associated with one or more specific cancer types.
Gene Matrix includes hereditary cancer testing with the Gene Matrix Membership — $89/month, or $59/month billed annually. Many insurance plans cover genetic testing for individuals who meet NCCN criteria, using CPT codes 81432, 81433, 81435, and 81479. We verify your coverage before you order.
A positive result means you carry a pathogenic variant that increases your cancer risk. You will receive a personalized screening and prevention plan based on NCCN guidelines, including earlier and more frequent screening (mammograms, MRIs, colonoscopies), risk-reducing medications like tamoxifen or aspirin, and in high-risk cases, discussion of prophylactic surgery. A board-certified genetic counselor walks you through every step.
No. A negative result means no pathogenic variants were found in the 108 genes tested. Your cancer risk returns to general population levels for those genes, but lifestyle, environment, and other genetic factors still play a role. Regular screening remains important for everyone.

Knowledge Saves Lives.

Hereditary cancers are highly preventable when you know your risk. The 108-gene panel gives you and your doctor the information needed to build a personalized prevention strategy.

Start Membership — $89/mo Talk to a Specialist
[ 108 Genes ][ 15+ Cancer Types ][ Results In 5–7 Days ]