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108-Gene Hereditary Cancer Panel

Hereditary Cancer
Genetic Testing

Know your risk for 15+ hereditary cancers before symptoms ever appear. Our 108-gene panel analyzes BRCA1, BRCA2, Lynch syndrome, TP53, PALB2, and 95+ more. Results in 5–7 days with genetic counseling.

Order Your TestSee Cancers Covered
CLIA Certified108 Genes5–7 Day ResultsGenetic Counselor Included
15+ Cancer Types

Every Major Hereditary Cancer, Covered

Our 108-gene panel screens for risk across all major hereditary cancer types. If you have a family history of any of these cancers, testing could save your life.

Breast Cancer

BRCA1, BRCA2, PALB2, TP53, PTEN, CDH1, STK11, ATM, CHEK2

General pop.~12%
Gene positiveUp to 72%

Ovarian Cancer

BRCA1, BRCA2, Lynch genes, RAD51C, RAD51D

General pop.~1.3%
Gene positiveUp to 44%

Colorectal Cancer

MLH1, MSH2, MSH6, PMS2, EPCAM, APC, MUTYH

General pop.~4%
Gene positiveUp to 80%

Pancreatic Cancer

BRCA2, PALB2, ATM, CDKN2A, STK11

General pop.~1.6%
Gene positiveUp to 10%

Prostate Cancer

BRCA2, BRCA1, HOXB13, ATM, CHEK2

General pop.~12%
Gene positiveUp to 60%

Melanoma Cancer

CDKN2A, CDK4, BAP1, MC1R, MITF

General pop.~2%
Gene positiveUp to 70%
Insurance Coverage

Do You Meet NCCN Criteria for Testing?

The National Comprehensive Cancer Network (NCCN) publishes guidelines that most insurance companies follow when deciding whether to cover hereditary cancer testing. If any of these apply to you, your test is likely covered.

Breast cancer diagnosed before age 50
Ovarian cancer at any age
Two or more primary breast cancers
Male breast cancer
Triple-negative breast cancer before age 60
Pancreatic cancer with breast/ovarian cancer in family
Colorectal or endometrial cancer before age 50
Ashkenazi Jewish ancestry with breast or ovarian cancer
Personal history of 10+ colorectal adenomas
A known pathogenic variant in a cancer gene in the family

Not sure if you qualify? Our team checks your insurance before you order.

Insurance Billing Codes

81432BRCA1/BRCA2 full gene sequence analysis
81433BRCA1/BRCA2 deletion/duplication analysis
81435Hereditary colon cancer gene panel (5+ genes)
81479Unlisted molecular pathology (multi-gene panels)
96040Genetic counseling (per 30 min session)

We handle pre-authorization, verify your benefits, and provide a superbill if you need to submit for reimbursement.

How Hereditary Cancer Testing Works

Step 1

Order Online

Choose a plan starting at $69/month. We ship your kit within 24 hours.

Step 2

Collect at Home

Swab both cheeks for 30 seconds. No blood, no needles. Mail back prepaid.

Step 3

Lab Analysis

Our CLIA lab sequences 108 cancer genes using NGS. Results in 5–7 days.

Step 4

Review & Plan

View your report. If positive, get a free genetic counseling session and screening plan.

Included with Essential — $69/mo

Get Hereditary Cancer Panel with Essential Plan

Hereditary Cancer Panel is included in your Essential Plan subscription — along with 10 other genetic tests. No per-test fees. No surprises.

All 11 genetic tests included
AI-powered analysis & insights
HIPAA-secure patient portal
Physician-ready PDF reports
Free DNA kit shipping
Genetic counselor consultations
Subscribe & Get Hereditary Cancer Panel — $69/mo

The Cost Comparison

Hereditary Cancer Panel individually

One-time purchase

$499

Essential Plan — all 11 tests

Monthly subscription

$69/mo

This test individually: $499. With your subscription: included at $69/mo along with 10 other tests.

Compare all 11 tests
Jennifer K.
“My mother had breast cancer at 42. I finally got tested and found out I carry a BRCA2 variant. My doctor immediately put me on an enhanced screening protocol. That test may have saved my life.”

Jennifer K.

Chicago, IL

BRCA2 pathogenic variant detected

Key Genes in the Panel

Our 108-gene panel includes the most clinically significant cancer susceptibility genes identified by NCCN, ACMG, and major cancer genetics societies.

BRCA1Very high

Breast, ovarian, prostate, pancreatic

BRCA2Very high

Breast, ovarian, prostate, pancreatic

TP53Very high

Breast, sarcoma, brain, adrenal (Li-Fraumeni)

PTENHigh

Breast, thyroid, endometrial (Cowden)

MLH1Very high

Colorectal, endometrial (Lynch)

MSH2Very high

Colorectal, endometrial (Lynch)

MSH6High

Colorectal, endometrial (Lynch)

PMS2Moderate-high

Colorectal, endometrial (Lynch)

APCVery high

Colorectal (FAP/AFAP)

CDH1Very high

Gastric, lobular breast

STK11Very high

Colorectal, breast, pancreatic (Peutz-Jeghers)

PALB2High

Breast, pancreatic

ATMModerate-high

Breast, pancreatic

CHEK2Moderate

Breast, colorectal, prostate

CDKN2AVery high

Melanoma, pancreatic

BAP1High

Mesothelioma, melanoma, renal

+ 92 additional genes covering rare and moderate-risk cancer syndromes

Frequently Asked Questions

Hereditary cancer genetic testing analyzes your DNA for mutations in genes that increase cancer risk. These mutations are inherited from a parent and can significantly raise the lifetime risk of developing breast, ovarian, colorectal, pancreatic, prostate, melanoma, and other cancers. Knowing your status lets you take preventive action before cancer develops.
Our hereditary cancer panel analyzes 108 genes associated with hereditary cancer syndromes. This includes BRCA1 and BRCA2 (breast/ovarian), Lynch syndrome genes (colorectal/endometrial), TP53 (Li-Fraumeni), PTEN (Cowden), APC (FAP), CDH1 (gastric), STK11 (Peutz-Jeghers), PALB2, CHEK2, ATM, and over 95 additional cancer susceptibility genes.
The panel screens for risk across 15+ cancer types including breast, ovarian, colorectal, endometrial, pancreatic, prostate, gastric, melanoma, thyroid, renal, and others. Each gene in the panel is associated with one or more specific cancer types.
Gene Matrix includes hereditary cancer testing in subscriptions starting at $69/month. Many insurance plans cover genetic testing for individuals who meet NCCN criteria, using CPT codes 81432, 81433, 81435, and 81479. We verify your coverage before you order.
A positive result means you carry a pathogenic variant that increases your cancer risk. You will receive a personalized screening and prevention plan based on NCCN guidelines, including earlier and more frequent screening (mammograms, MRIs, colonoscopies), risk-reducing medications like tamoxifen or aspirin, and in high-risk cases, discussion of prophylactic surgery. A board-certified genetic counselor walks you through every step.
No. A negative result means no pathogenic variants were found in the 108 genes tested. Your cancer risk returns to general population levels for those genes, but lifestyle, environment, and other genetic factors still play a role. Regular screening remains important for everyone.

Knowledge Saves Lives.

Hereditary cancers are highly preventable when you know your risk. The 108-gene panel gives you and your doctor the information needed to build a personalized prevention strategy.

Get Your Test — $69/moTalk to a Specialist

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