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Advanced Neurogenomics

GeneMind

Mental Wellness Genetics

Unlock the genetic blueprint of your mental health. Analyze 95+ genes affecting mood, stress response, neurotransmitter function, and medication response for personalized mental wellness strategies.

Mood Disorders
Neurotransmitters
Stress Response
Cognitive Function
Sleep & Circadian
Medication Response
Subscribe & Get GeneMind — $89/moView Sample Report
CLIA Certified
HIPAA Compliant
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Your Mental Health DNA

Comprehensive Analysis

Genes Analyzed
95+
Neurotransmitter Mapping
100%
Accuracy Rate
99.2%
Day Results
5-7
Sample Genetic InsightsPersonalized
Mood Stability78%
Stress Resilience65%
Cognitive Function88%
Sleep Quality72%
Explore
95+ Genetic Markers

Every Dimension of Your Mental Wellness. Decoded.

95+ genes analyzed across 6 areas — each revealing something powerful about how your brain, mood, and mind work.

Why Do You Feel the Way You Feel?
28+ genes
Mood Disorders

Why Do You Feel the Way You Feel?

Your genetic risk for depression, anxiety, and mood swings — decoded at the DNA level.

Depression RiskAnxiety PredispositionBipolar MarkersSeasonal Patterns
The Brain Chemistry Behind Everything
22+ genes
Neurotransmitter Function

The Brain Chemistry Behind Everything

How your serotonin, dopamine and GABA genes shape your emotions, motivation, and mental balance.

Serotonin PathwaysDopamine RegulationGABA FunctionNorepinephrine Balance
Why Stress Hits You Harder
18+ genes
Stress Response

Why Stress Hits You Harder

Stop guessing. Your genes predict how you respond to antidepressants.

How Your Brain Performs
15+ genes
Cognitive Function

How Your Brain Performs

Memory, focus, and learning speed — all genetically influenced.

Why You Cannot Sleep
12+ genes
Sleep & Circadian Rhythm

Why You Cannot Sleep

Your circadian clock genes reveal why sleep eludes you.

Find Meds That Work for You
20+ genes
Medication Response

Find Meds That Work for You

Stop guessing. Your genes predict how you respond to antidepressants.

Clinical-Grade Quality You Can Trust

What's Inside the GeneMind Test

The same laboratory quality hospitals use — made simple, accessible, and actionable for you.

Test at a Glance

95+ Genes
Comprehensive panel coverage
5–7 business days
From lab to your inbox
Buccal swab (at-home) or saliva collection kit
Simple at-home collection
Next-generation sequencing (NGS) with pharmacogenomic star-allele calling
CAP-validated accuracy
CLIA, CAP, CE-IVD
Fully certified laboratory
Insurance Billing Codes
8147981401

These codes help your insurance process reimbursement. Coverage depends on your plan — we help verify.

Insurance & Coverage

Often covered by insurance
May not need prior approval
Typical requirements:
  • Patient starting or currently on psychiatric medication
  • Treatment-resistant depression or anxiety
  • Significant adverse drug reactions to psychotropics
  • Family history of psychiatric medication non-response
Check My Coverage

The Genes We Test (95+)

SLC6A4
17q11.2
MTHFR
1p36.22
COMT
22q11.21
BDNF
11p14.1
DRD2
11q23.1
HTR2A
13q14.2
CYP2D6
22q13.2
CYP2C19
10q24.1
HTR2C
Xq23
NR3C1
5q31.3
FKBP5
6p21.31
ADORA2A
22q11.23
CLOCK
4q12
PER2
2q37.3
ANK3
10q21.2
CACNA1C
12p13.3

Is This Test Right for You?

  • 1
    Patients with treatment-resistant depression or anxiety
  • 2
    Individuals starting psychiatric medication for the first time
  • 3
    Patients experiencing significant medication side effects
  • 4
    Those with a family history of mood disorders or addiction
  • 5
    People seeking personalized mental wellness strategies
  • 6
    Patients with ADHD considering stimulant therapy

What Your Report Includes

Mood disorder risk assessment — depression, anxiety, bipolar markers
Neurotransmitter pathway analysis — serotonin, dopamine, GABA, norepinephrine
Stress response genetics — cortisol regulation, HPA axis function, resilience
Cognitive function screening — memory, focus, learning capacity
Sleep and circadian rhythm genetics — insomnia risk, chronotype
Pharmacogenomic medication guide — antidepressant and antipsychotic response
Personalized supplement and lifestyle mental wellness plan
Provider-ready summary for psychiatrist or therapist

How to Get Started

Order Kit

Order online or through your mental health provider. Free shipping.

Collect DNA

2-minute cheek swab at home. Mail back prepaid.

Lab Analysis

CLIA lab analyzes 95+ mental health and medication genes.

Get Results

Personalized psychiatric medication guide with CPIC/FDA references.

Order as a ProviderOrder as a PatientPreview Report
Real Sample Data

Sample Report

Explore a comprehensive GeneMind report with detailed genetic insights, personalized recommendations, and actionable mental wellness strategies

GeneMind Report

Mental Wellness Genetics Analysis

Report ID
GM-2024-087456
Collection Date
2024-01-15
Report Date
2024-01-22
Lab ID
14D2276402
NPI
1225729312
Ethnicity
European

Executive Summary

95
Genes Analyzed
42
Variants Detected
28
Mental Health Insights
15
Neurotransmitter Findings
34
Actionable Recommendations
SLC6A4 - 5-HTTLPR

rs25531 | Genotype: S/S

High Impact

The short (S) allele of the serotonin transporter gene is associated with reduced serotonin transporter expression and function. This variant has been linked to increased susceptibility to depression and anxiety disorders, particularly in response to stressful life events.

Recommendation

Consider cognitive behavioral therapy (CBT) and mindfulness-based stress reduction. Regular exercise and omega-3 supplementation may help support serotonin function. Discuss SSRI options with your healthcare provider if symptoms persist.

BDNF - Val66Met

rs6265 | Genotype: Val/Met

Moderate Impact

This variant affects brain-derived neurotrophic factor (BDNF) secretion and neuroplasticity. The Met allele is associated with reduced BDNF activity and has been linked to increased risk of mood disorders and altered response to antidepressants.

Recommendation

Engage in regular aerobic exercise to boost BDNF levels. Consider learning-based activities and cognitive training. Adequate sleep and stress management are crucial for optimal BDNF function.

MTHFR - C677T

rs1801133 | Genotype: C/T

Moderate Impact

This variant reduces MTHFR enzyme activity, affecting folate metabolism and methylation processes. It has been associated with increased risk of depression and may impact response to certain antidepressants.

Recommendation

Ensure adequate intake of methylated B vitamins (L-methylfolate, methylcobalamin). Consider supplementation with 400-800mcg of L-methylfolate daily. Maintain a diet rich in leafy greens and folate-rich foods.

TPH2 - G-703T

rs4570625 | Genotype: G/T

Moderate Impact

Tryptophan hydroxylase 2 is the rate-limiting enzyme in serotonin synthesis in the brain. This variant may affect serotonin production and has been associated with mood regulation difficulties.

Recommendation

Ensure adequate tryptophan intake through diet (turkey, eggs, nuts, seeds). Consider 5-HTP supplementation under medical supervision. Maintain regular sleep-wake cycles to support serotonin production.

Pharmacogenomics

Medication Response Analysis

Sertraline (Zoloft)
SSRI Antidepressant
Normal Metabolizer
Escitalopram (Lexapro)
SSRI Antidepressant
Poor Metabolizer
Venlafaxine (Effexor)
SNRI Antidepressant
Poor Metabolizer

Mental Wellness Plan

Personalized Recommendations

Exercise Protocol

Engage in 150 minutes of moderate-intensity aerobic exercise weekly (30 minutes, 5 days). Include 2-3 strength training sessions. Morning exercise may be particularly beneficial for your circadian rhythm variants. Exercise boosts BDNF, supports neurotransmitter balance, and improves stress resilience.

Sleep Hygiene

Maintain consistent sleep-wake times (even on weekends). Aim for 7-9 hours nightly. Create a dark, cool sleep environment (65-68°F). Limit blue light exposure 2-3 hours before bed. Consider blackout curtains and white noise if needed. Your CLOCK and PER2 variants make sleep consistency especially important.

Supplement Plan
L-Methylfolate - 400-800 mcg daily
Omega-3 (EPA/DHA) - 1000-2000 mg daily

Complete report includes all genetic findings, wellness plans, and detailed recommendations

Ready to Download Your Sample Report?

Get instant access to a comprehensive GeneMind report with detailed genetic insights, personalized mental wellness strategies, and actionable recommendations

Questions Mental Health Patients Ask

Your Mental Health Has
A Genetic Blueprint

If medications haven't worked, stress hits harder for you than others, or you've always felt your mental health is different — your genes hold the explanation.

"Why do antidepressants never seem to work for me?"

Psychiatric medication failure is often not a diagnosis problem — it's a pharmacogenomics problem your prescriber may not know about.

"Why do antidepressants never seem to work for me?"
CYP2D6 / CYP2C19 / SLC6A4

What the Science Says

Up to 99% of people carry at least one pharmacogenomic variant affecting psychiatric medication metabolism. CYP2D6 affects antidepressants like fluoxetine, paroxetine, and venlafaxine. CYP2C19 affects citalopram, escitalopram, and sertraline — among the most prescribed antidepressants in the US. If you're an ultra-rapid or poor metabolizer, standard doses either do nothing or cause immediate side effects. SLC6A4 affects serotonin transporter activity, determining your baseline serotonin response.

How GeneMind Helps

GeneMind maps your complete psychiatric pharmacogenomics profile — telling you and your psychiatrist exactly which antidepressants, anxiolytics, and mood stabilizers your biology is most likely to respond to before you spend months on the wrong medication.

The average psychiatric patient tries 3.4 medications before finding one that works — pharmacogenomic testing cuts this to under 1.5

"Is my anxiety or depression something I inherited?"

Mental health conditions don't come out of nowhere — and understanding the genetic component changes how you approach it.

"Is my anxiety or depression something I inherited?"
BDNF / SERT / TPH2

What the Science Says

BDNF (Brain-Derived Neurotrophic Factor) variants affect how your brain creates new neural connections — lower BDNF activity is strongly associated with depression and treatment resistance. The SERT gene controls serotonin reuptake rates, affecting your baseline mood stability. TPH2 regulates serotonin production in the brain's raphe nuclei. These are the biological underpinnings that turn stress or life events into clinical depression for some people and not others.

How GeneMind Helps

GeneMind identifies your neurogenetic risk factors for mood disorders — providing objective information to help you and your mental health provider make proactive decisions about therapy, lifestyle interventions, and early treatment before a crisis.

Heritability estimates for depression range from 37-50%, meaning genetics explains roughly half of your risk

"Why am I so much more sensitive to stress than others?"

If you've always felt stress hits harder for you than for people around you, your HPA axis genetics may explain why.

"Why am I so much more sensitive to stress than others?"
FKBP5 / NR3C1 / COMT

What the Science Says

FKBP5 is one of the most studied genes in stress biology — certain variants cause elevated cortisol response to mild stressors, difficulty returning to baseline after stress, and significantly higher PTSD risk after trauma. NR3C1 affects glucocorticoid receptor sensitivity — how strongly your cells respond to stress hormones. COMT affects how quickly your prefrontal cortex degrades dopamine and norepinephrine during stress, influencing your recovery time.

How GeneMind Helps

GeneMind's stress response panel gives you and your therapist a biological map of your stress system — the genetic basis for why mindfulness or exercise works differently for you than for someone else, and which stress management interventions align with your neurogenetics.

FKBP5 variants are found in 20% of the population and increase PTSD risk by 4x after trauma exposure

Understanding your mental health genetics is the first step toward real, lasting change.

Decode Your Mental Wellness DNA
Real People. Real Breakthroughs.

The Gene That Finally
Made Sense of It All

For years they wondered why treatment wasn't working. Their genes had the answer all along.

Sarah J.
Gene Discovery
CYP2C19 Ultra-Rapid Metabolizer + SLC6A4 Short Variant
SSRIs metabolize too fast; serotonin transporter highly active
Sarah J.
34, Seattle, WA • Graphic Designer

“I tried four different SSRIs over three years. Each one either did nothing or made me feel worse within days. My psychiatrist was running out of ideas and I was starting to think therapy just didn't work for me. GeneMind showed I'm a CYP2C19 ultra-rapid metabolizer — my liver processes SSRIs so quickly they never reach therapeutic levels in my blood. My psychiatrist switched to an SNRI that uses a different metabolic pathway. Within six weeks I felt better than I had in a decade.”

The Outcome

Found the right medication class on the first try after pharmacogenomics. Life-changing improvement after 3 years of failed treatments.

Daniel H.
Gene Discovery
FKBP5 Risk Variant + BDNF Val66Met
Elevated cortisol response; impaired BDNF activity under stress
Daniel H.
28, Chicago, IL • Graduate Student

“Graduate school hit me harder than it did my peers. I burned out during my first semester while classmates seemed fine. My therapist was helpful but couldn't explain why I recovered so much slower from setbacks. GeneMind revealed I have the FKBP5 risk variant that causes my cortisol to spike higher and stay elevated longer under stress, plus a BDNF variant that slows my brain's recovery from stressful events. With this information, my therapist shifted my treatment completely — we focused on cortisol regulation, sleep, and exercise timing. My recovery time from stressful events dropped dramatically.”

The Outcome

Therapy approach redesigned based on genetic stress profile. Academic performance stabilized and resilience measurably improved.

Lisa K.
Gene Discovery
COMT Val158Met + MTHFR A1298C
Dopamine clearance highly active; folate conversion impaired
Lisa K.
47, Boston, MA • Clinical Psychologist

“As a psychologist I recommend genetic testing to my patients — but I'd never done it myself. My GeneMind results were eye-opening. I have an active COMT variant that clears dopamine very quickly from my prefrontal cortex, making me highly productive under stress but vulnerable to burnout and anxiety in low-stimulation periods. I also have MTHFR, explaining years of mild depression despite excellent lifestyle habits. Switching to methylfolate and understanding my dopamine profile completely changed how I structure my work and self-care.”

The Outcome

Implemented methylfolate and lifestyle protocol changes. Mood stabilized significantly. Now recommends GeneMind to her patients.

95+
Genes Analyzed
25+
Medications Mapped
22,000+
Reports Delivered
4.9/5
Patient Rating
Simple 4-Step Process

From Swab to
Mental Wellness Blueprint

A complete neurogenetic profile in 5-7 days — from your couch, no clinic visits required.

Your Mental Wellness Kit Ships Free
1
Step 1

Your Mental Wellness Kit Ships Free

A simple at-home collection kit arrives in 2-3 business days. It contains a sterile cheek swab, collection tube, prepaid return envelope, and step-by-step instructions. No appointment, no clinic visit, no blood draw.

Free two-way shipping. Arrives in 2-3 business days anywhere in the US.
A Quick Cheek Swab at Home
2
Step 2

A Quick Cheek Swab at Home

Swab the inside of your cheek for 30 seconds, cap the tube, seal the prepaid envelope, and drop it in any mailbox. That's it. No special preparation, no fasting, no stress. Your DNA doesn't change based on your current mood.

Takes 2 minutes. Can be done any time of day, any day.
We Analyze 95+ Mental Health Genes
3
CLIA Certified
HIPAA Compliant
CE-IVD Certified
MD Reviewed
Step 3

We Analyze 95+ Mental Health Genes

Your sample is processed in our CLIA-certified laboratory. We sequence every gene related to your neurotransmitter function, stress response, mood disorders, cognitive performance, sleep patterns, and psychiatric medication metabolism. Reviewed by board-certified geneticists.

Your Mental Wellness Blueprint
4
Step 4

Your Mental Wellness Blueprint

In 5-7 days your comprehensive report is available in your secure portal. Share it with your psychiatrist, therapist, or GP. It includes your pharmacogenomics profile for psychiatric medications, neurotransmitter genetic insights, stress response analysis, and personalized mental wellness recommendations.

Share instantly with your psychiatrist, therapist, or GP for better treatment decisions.

Results in 5-7 Days

Your neurogenetic blueprint — shared with any provider, forever.

Order Your KitSee Sample Report
Included with Premium — $89/mo

Get GeneMind with Premium Plan

GeneMind is included in your Premium Plan subscription — along with 10 other genetic tests. No per-test fees. No surprises.

All 11 genetic tests included
AI-powered analysis & insights
HIPAA-secure patient portal
Physician-ready PDF reports
Free DNA kit shipping
Genetic counselor consultations
Subscribe & Get GeneMind — $89/mo

The Cost Comparison

GeneMind individually

One-time purchase

$349

Premium Plan — all 11 tests

Monthly subscription

$89/mo

This test individually: $349. With your subscription: included at $89/mo along with 10 other tests.

Compare all 11 tests
Also Included in Your Premium Plan

GeneMind is just the beginning

Your subscription unlocks all 11 tests. Here are a few more you get at no extra cost:

GenePGx

Optimize psychiatric medication selection with pharmacogenomics testing.

Explore GenePGx

GeneDiet

Nutrition genetics — the gut-brain connection and mood-supporting foods.

Explore GeneDiet

GeneResilience

Stress response, cortisol regulation, and longevity genetics.

Explore GeneResilience
Aisha M.
“After years of trying different antidepressants with no success, GeneMind revealed I have an MTHFR variant affecting folate metabolism and a serotonin transporter variant. My psychiatrist completely changed my treatment plan. I finally feel stable.”

Aisha M.

Atlanta, GA

MTHFR + SLC6A4 variants identified

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GenePGx

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GeneSport

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Contact Support

Get expert guidance

For Providers

Learn about our CLIA-certified lab and team

Learn More About Mental Health Genetics

Latest Research

Read neurogenomics and mental health articles

About Gene Matrix

Learn about our CLIA-certified lab and team

FAQ & Support

Find answers to common questions

Frequently Asked Questions

GeneMind analyzes over 95 genetic markers that influence neurotransmitter function, stress response, mood regulation, and medication metabolism. This information helps healthcare providers personalize treatment plans, predict medication responses, and identify risk factors for mental health conditions, leading to more effective and targeted interventions.
No, GeneMind does not diagnose mental health conditions. It identifies genetic predispositions and risk factors that may influence your mental health. This information should be used in conjunction with clinical evaluation by qualified mental health professionals to inform treatment decisions and preventive strategies.
Yes! GeneMind includes pharmacogenomic analysis that examines how your genes affect medication metabolism and response. This can help your healthcare provider select medications that are more likely to be effective for you and avoid those that may cause side effects or be less effective based on your genetic profile.
Absolutely. We take your privacy extremely seriously. Your genetic data is encrypted, stored securely, and never shared with third parties without your explicit consent. We comply with HIPAA, GDPR, and all applicable privacy regulations. You maintain full ownership and control of your genetic information.
GeneMind uses state-of-the-art sequencing technology with 99.2% accuracy. Our analysis is based on peer-reviewed scientific research and validated genetic markers. However, it's important to remember that genetics is just one factor in mental health—environment, lifestyle, and experiences also play crucial roles.
Your genetic code remains constant, but our understanding of how genes influence mental health continues to evolve. Premium and Family plan members receive quarterly updates as new research emerges and our analysis algorithms improve, ensuring you always have access to the latest scientific insights.

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