GeneMind
Mental Wellness Genetics
Unlock the genetic blueprint of your mental health. Analyze 95+ genes affecting mood, stress response, neurotransmitter function, and medication response for personalized mental wellness strategies.
Your Mental Health DNA
Comprehensive Analysis
Every Dimension of Your Mental Wellness. Decoded.
95+ genes analyzed across 6 areas — each revealing something powerful about how your brain, mood, and mind work.
Why Do You Feel the Way You Feel?
Your genetic risk for depression, anxiety, and mood swings — decoded at the DNA level.
The Brain Chemistry Behind Everything
How your serotonin, dopamine and GABA genes shape your emotions, motivation, and mental balance.
Why Stress Hits You Harder
Stop guessing. Your genes predict how you respond to antidepressants.
How Your Brain Performs
Memory, focus, and learning speed — all genetically influenced.
Why You Cannot Sleep
Your circadian clock genes reveal why sleep eludes you.
Find Meds That Work for You
Stop guessing. Your genes predict how you respond to antidepressants.
Choose YourHealth Journey
Comprehensive genetic testing subscriptions with your GeneMatrix AI DNA Kit included
Essential
Perfect for getting started
or $55/mo billed annuallySave 20%
What's included
- 10 Genetic tests per year
- 1 Annual cancer screening (108 genes)
- 1 Annual PGx (pharmacogenomics) test
- 77+ cancer types covered
- Basic pharmacogenomics (50 drugs)
- AI-powered health reports
- Basic risk assessments
- Personalized recommendations
- GeneMatrix mobile app
- Secure health dashboard
- Email support
- Downloadable PDF reports
- Ancestry insights
- Advanced predictive analytics
- Genetic counselor session
- Family health sharing
- Physician portal access
Premium
Most comprehensive coverage
or $71/mo billed annuallySave 20%
What's included
- 10 Genetic tests per year
- 2 Cancer screenings annually (188 genes)
- 2 PGx (pharmacogenomics) tests annually
- 120+ cancer types covered
- Full pharmacogenomics (350+ drugs)
- GeneMind mental health panel
- GeneDiet nutrition analysis
- Advanced AI health reports
- Comprehensive risk assessments
- Predictive health analytics
- Drug interaction alerts
- Priority email & chat support
- 1 Genetic counselor session/year
- Priority 48-hour processing
- Comprehensive PDF reports
- Family health sharing (2 members)
- Physician portal access
Family
Complete family protection
or $111/mo billed annuallySave 20%
What's included
- Coverage for up to 4 family members
- 4 Tests per member per year
- Bi-annual 188-gene screening for all
- 120+ cancer types per member
- Full pharmacogenomics for all
- GeneBaby pediatric panels
- Carrier screening for parents
- Family genetic risk mapping
- Cross-generational insights
- Hereditary condition tracking
- Shared family dashboard
- Dedicated account manager
- 4 Genetic counselor sessions/year
- VIP 24-hour processing
- 24/7 priority support
- Unlimited family sharing
Enterprise Solutions
Custom genetic testing programs for healthcare organizations, employers, and research institutions.
See Exactly WhatYou're Getting
Every single feature, side by side — so there are no surprises when you subscribe.
vs. purchasing 10 individual tests separately at ~$2,750/yr
vs. purchasing every Premium feature individually at ~$6,100/yr
vs. full individual plans for 4 family members at ~$24,400/yr
Questions about which plan fits your health goals?
Talk to a Genetic Counselor — Free ConsultationAll plans include your GeneMatrix AI DNA Kit
Sample Report
Explore a comprehensive GeneMind report with detailed genetic insights, personalized recommendations, and actionable mental wellness strategies
GeneMind Report
Mental Wellness Genetics Analysis
Executive Summary
SLC6A4 - 5-HTTLPR
rs25531 | Genotype: S/S
The short (S) allele of the serotonin transporter gene is associated with reduced serotonin transporter expression and function. This variant has been linked to increased susceptibility to depression and anxiety disorders, particularly in response to stressful life events.
Consider cognitive behavioral therapy (CBT) and mindfulness-based stress reduction. Regular exercise and omega-3 supplementation may help support serotonin function. Discuss SSRI options with your healthcare provider if symptoms persist.
BDNF - Val66Met
rs6265 | Genotype: Val/Met
This variant affects brain-derived neurotrophic factor (BDNF) secretion and neuroplasticity. The Met allele is associated with reduced BDNF activity and has been linked to increased risk of mood disorders and altered response to antidepressants.
Engage in regular aerobic exercise to boost BDNF levels. Consider learning-based activities and cognitive training. Adequate sleep and stress management are crucial for optimal BDNF function.
MTHFR - C677T
rs1801133 | Genotype: C/T
This variant reduces MTHFR enzyme activity, affecting folate metabolism and methylation processes. It has been associated with increased risk of depression and may impact response to certain antidepressants.
Ensure adequate intake of methylated B vitamins (L-methylfolate, methylcobalamin). Consider supplementation with 400-800mcg of L-methylfolate daily. Maintain a diet rich in leafy greens and folate-rich foods.
TPH2 - G-703T
rs4570625 | Genotype: G/T
Tryptophan hydroxylase 2 is the rate-limiting enzyme in serotonin synthesis in the brain. This variant may affect serotonin production and has been associated with mood regulation difficulties.
Ensure adequate tryptophan intake through diet (turkey, eggs, nuts, seeds). Consider 5-HTP supplementation under medical supervision. Maintain regular sleep-wake cycles to support serotonin production.
Pharmacogenomics
Medication Response Analysis
Mental Wellness Plan
Personalized Recommendations
Engage in 150 minutes of moderate-intensity aerobic exercise weekly (30 minutes, 5 days). Include 2-3 strength training sessions. Morning exercise may be particularly beneficial for your circadian rhythm variants. Exercise boosts BDNF, supports neurotransmitter balance, and improves stress resilience.
Maintain consistent sleep-wake times (even on weekends). Aim for 7-9 hours nightly. Create a dark, cool sleep environment (65-68°F). Limit blue light exposure 2-3 hours before bed. Consider blackout curtains and white noise if needed. Your CLOCK and PER2 variants make sleep consistency especially important.
Complete report includes all genetic findings, wellness plans, and detailed recommendations
Ready to Download Your Sample Report?
Get instant access to a comprehensive GeneMind report with detailed genetic insights, personalized mental wellness strategies, and actionable recommendations
Your Mental Health Has
A Genetic Blueprint
If medications haven't worked, stress hits harder for you than others, or you've always felt your mental health is different — your genes hold the explanation.
"Why do antidepressants never seem to work for me?"
Psychiatric medication failure is often not a diagnosis problem — it's a pharmacogenomics problem your prescriber may not know about.
What the Science Says
Up to 99% of people carry at least one pharmacogenomic variant affecting psychiatric medication metabolism. CYP2D6 affects antidepressants like fluoxetine, paroxetine, and venlafaxine. CYP2C19 affects citalopram, escitalopram, and sertraline — among the most prescribed antidepressants in the US. If you're an ultra-rapid or poor metabolizer, standard doses either do nothing or cause immediate side effects. SLC6A4 affects serotonin transporter activity, determining your baseline serotonin response.
GeneMind maps your complete psychiatric pharmacogenomics profile — telling you and your psychiatrist exactly which antidepressants, anxiolytics, and mood stabilizers your biology is most likely to respond to before you spend months on the wrong medication.
"Is my anxiety or depression something I inherited?"
Mental health conditions don't come out of nowhere — and understanding the genetic component changes how you approach it.
What the Science Says
BDNF (Brain-Derived Neurotrophic Factor) variants affect how your brain creates new neural connections — lower BDNF activity is strongly associated with depression and treatment resistance. The SERT gene controls serotonin reuptake rates, affecting your baseline mood stability. TPH2 regulates serotonin production in the brain's raphe nuclei. These are the biological underpinnings that turn stress or life events into clinical depression for some people and not others.
GeneMind identifies your neurogenetic risk factors for mood disorders — providing objective information to help you and your mental health provider make proactive decisions about therapy, lifestyle interventions, and early treatment before a crisis.
"Why am I so much more sensitive to stress than others?"
If you've always felt stress hits harder for you than for people around you, your HPA axis genetics may explain why.
What the Science Says
FKBP5 is one of the most studied genes in stress biology — certain variants cause elevated cortisol response to mild stressors, difficulty returning to baseline after stress, and significantly higher PTSD risk after trauma. NR3C1 affects glucocorticoid receptor sensitivity — how strongly your cells respond to stress hormones. COMT affects how quickly your prefrontal cortex degrades dopamine and norepinephrine during stress, influencing your recovery time.
GeneMind's stress response panel gives you and your therapist a biological map of your stress system — the genetic basis for why mindfulness or exercise works differently for you than for someone else, and which stress management interventions align with your neurogenetics.
Understanding your mental health genetics is the first step toward real, lasting change.
Decode Your Mental Wellness DNAThe Gene That Finally
Made Sense of It All
For years they wondered why treatment wasn't working. Their genes had the answer all along.
“I tried four different SSRIs over three years. Each one either did nothing or made me feel worse within days. My psychiatrist was running out of ideas and I was starting to think therapy just didn't work for me. GeneMind showed I'm a CYP2C19 ultra-rapid metabolizer — my liver processes SSRIs so quickly they never reach therapeutic levels in my blood. My psychiatrist switched to an SNRI that uses a different metabolic pathway. Within six weeks I felt better than I had in a decade.”
Found the right medication class on the first try after pharmacogenomics. Life-changing improvement after 3 years of failed treatments.
“Graduate school hit me harder than it did my peers. I burned out during my first semester while classmates seemed fine. My therapist was helpful but couldn't explain why I recovered so much slower from setbacks. GeneMind revealed I have the FKBP5 risk variant that causes my cortisol to spike higher and stay elevated longer under stress, plus a BDNF variant that slows my brain's recovery from stressful events. With this information, my therapist shifted my treatment completely — we focused on cortisol regulation, sleep, and exercise timing. My recovery time from stressful events dropped dramatically.”
Therapy approach redesigned based on genetic stress profile. Academic performance stabilized and resilience measurably improved.
“As a psychologist I recommend genetic testing to my patients — but I'd never done it myself. My GeneMind results were eye-opening. I have an active COMT variant that clears dopamine very quickly from my prefrontal cortex, making me highly productive under stress but vulnerable to burnout and anxiety in low-stimulation periods. I also have MTHFR, explaining years of mild depression despite excellent lifestyle habits. Switching to methylfolate and understanding my dopamine profile completely changed how I structure my work and self-care.”
Implemented methylfolate and lifestyle protocol changes. Mood stabilized significantly. Now recommends GeneMind to her patients.
From Swab to
Mental Wellness Blueprint
A complete neurogenetic profile in 5-7 days — from your couch, no clinic visits required.
Your Mental Wellness Kit Ships Free
A simple at-home collection kit arrives in 2-3 business days. It contains a sterile cheek swab, collection tube, prepaid return envelope, and step-by-step instructions. No appointment, no clinic visit, no blood draw.
A Quick Cheek Swab at Home
Swab the inside of your cheek for 30 seconds, cap the tube, seal the prepaid envelope, and drop it in any mailbox. That's it. No special preparation, no fasting, no stress. Your DNA doesn't change based on your current mood.
We Analyze 95+ Mental Health Genes
Your sample is processed in our CLIA-certified laboratory. We sequence every gene related to your neurotransmitter function, stress response, mood disorders, cognitive performance, sleep patterns, and psychiatric medication metabolism. Reviewed by board-certified geneticists.
Your Mental Wellness Blueprint
In 5-7 days your comprehensive report is available in your secure portal. Share it with your psychiatrist, therapist, or GP. It includes your pharmacogenomics profile for psychiatric medications, neurotransmitter genetic insights, stress response analysis, and personalized mental wellness recommendations.
Results in 5-7 Days
Your neurogenetic blueprint — shared with any provider, forever.
Get GeneMind with Premium Plan
GeneMind is included in your Premium Plan subscription — along with 10 other genetic tests. No per-test fees. No surprises.
The Cost Comparison
GeneMind individually
One-time purchase
$349
Premium Plan — all 11 tests
Monthly subscription
$89/mo
This test individually: $349. With your subscription: included at $89/mo along with 10 other tests.
GeneMind is just the beginning
Your subscription unlocks all 11 tests. Here are a few more you get at no extra cost:
“After years of trying different antidepressants with no success, GeneMind revealed I have an MTHFR variant affecting folate metabolism and a serotonin transporter variant. My psychiatrist completely changed my treatment plan. I finally feel stable.”
Aisha M.
Atlanta, GA
MTHFR + SLC6A4 variants identified
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GeneSport
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Frequently Asked Questions
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Begin your personalized mental wellness journey with GeneMind
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