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GeneCore Comprehensive Genetic Health Screening
Most Comprehensive Genetic Test

GeneCoreComplete Health Screening

One simple cheek swab. 130+ genes analyzed. A 45-page roadmap written in plain English that tells you exactly what your DNA means for your heart, metabolism, brain, immune system, bones, and how your body processes medications.

Cardiovascular HealthMetabolic FunctionImmune SystemDetoxificationBone HealthCognitive Function
Subscribe & Get GeneCore — $69/mo View Sample Report
CLIA Certified Lab
HIPAA Compliant
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Explore
130+
Genes Analyzed
Most comprehensive panel available
6
Health Categories
Heart, metabolism, brain & more
99.9%
Lab Accuracy
CLIA-certified results you can trust
45+
Page Report
Plain English — no jargon
Plain English Insights

What Your DNA Actually Tells You

Not raw data and gene codes — real answers to questions you've probably been asking your whole life.

"Why do I gain weight even when I eat well?"
"Why do I gain weight even when I eat well?"

Your FTO and MC4R genes control hunger signals and fat storage. Some people are genetically wired to feel hungrier, store more fat, and burn fewer calories — no matter what they do.

Recommendation

GeneCore tells you exactly which metabolic variants you carry and which diet type matches your DNA.

"Why do I feel exhausted even after 8 hours of sleep?"
"Why do I feel exhausted even after 8 hours of sleep?"

MTHFR gene variants block your body from converting folic acid to its active form, causing low energy, brain fog, and poor recovery. About 1 in 3 people carry this variant and don't know it.

Recommendation

GeneCore identifies methylation gene variants and recommends the exact supplement form your body can actually use.

"Should I be worried about my heart as I get older?"
"Should I be worried about my heart as I get older?"

The APOE gene — carried by 25% of the population — significantly raises cardiovascular and Alzheimer's risk. Most people discover it too late. Early detection changes your prevention strategy.

Recommendation

GeneCore analyzes 25 cardiovascular genes and gives you a personalized prevention plan years before symptoms appear.

6 Health Categories

Every Area of Your Health. Covered.

130+ genes analyzed across 6 categories — each one revealing something actionable about your health.

Cardiovascular Health
25 genes

Cardiovascular Health

Will your heart thank you or warn you?

Learn if you carry variants that raise cholesterol, affect blood pressure, or increase clotting risk — so you can act before symptoms appear.

What you\'ll discover
Your natural LDL cholesterol tendency
Blood pressure genetic risk factors
Heart attack & stroke predisposition
Response to heart medications
APOEMTHFRACEAGTCETP+20 more
Metabolic Function
30 genes

Metabolic Function

Why some diets work for others but not you.

Your metabolism is written in your DNA. Discover why you may store fat differently, how your body processes sugar, and which diet type actually fits your genes.

What you\'ll discover
Weight gain & fat storage tendencies
Blood sugar regulation & diabetes risk
How your body uses carbs vs fats
Metabolism speed & calorie burning
FTOMC4RPPARGTCF7L2ADIPOQ+25 more
Immune System
20 genes

Immune System

Why do you get sick more — or less — than others?

Your immune genes determine how aggressively your body fights infection, manages inflammation, and responds to autoimmune triggers. This changes everything about prevention.

What you\'ll discover
Inflammatory response strength
Autoimmune condition susceptibility
Infection & virus resistance
Allergy & sensitivity predispositions
HLA-BIL6TNFIFNGCCR5+15 more
Detoxification
18 genes

Detoxification

How well does your liver actually clean your blood?

Your detox genes control how fast you process caffeine, alcohol, medications, and environmental toxins. Some people are slow metabolizers — and never know it.

What you\'ll discover
Caffeine metabolism speed
Alcohol & toxin processing ability
Medication clearance rate
Environmental chemical sensitivity
CYP1A2CYP2C9GSTM1GSTT1NAT2+13 more
Bone Health
15 genes

Bone Health

Are your bones silently losing density?

Bone loss is invisible until it breaks. Your genes reveal your vitamin D absorption, calcium metabolism, and osteoporosis risk — decades before a fracture.

What you\'ll discover
Vitamin D receptor efficiency
Calcium absorption capacity
Osteoporosis & fracture risk
Joint & collagen strength genes
VDRCOL1A1LRP5ESR1CALCR+10 more
Cognitive Function
22 genes

Cognitive Function

How long will your mind stay sharp?

Your brain genes affect memory, focus, mood regulation, and long-term dementia risk. The APOE gene alone can significantly shift your Alzheimer's probability.

What you\'ll discover
Memory & learning gene variants
Alzheimer's & dementia risk factors
Focus, mood & dopamine genetics
Stress resilience & mental fatigue
BDNFCOMTAPOEKIBRACHRNA4+17 more

From Swab to Life-Changing Insights

The entire process takes about 5 minutes of your time. We handle everything else.

Order Your Kit
1

Order Your Kit

Choose your plan and we'll ship a simple collection kit right to your door — usually in 2-3 business days.

Free express shipping both ways. No appointment needed. No lab visit.
Swab at Home
2

Swab at Home

The kit contains a simple cheek swab. Takes less than 2 minutes. No needles, no blood, no hassle.

Simple, painless, and done in under 2 minutes from your couch.
Mail It Back
3

Mail It Back

Seal your sample in the prepaid return envelope and drop it in any mailbox. We handle everything from there.

Prepaid shipping label included. Drop it in any mailbox — done.
Read Your Results
4

Read Your Results

Your 45+ page personalized report lands in your secure online portal, with a plain-English breakdown of every finding.

Plain English explanations. No PhD required to understand your results.
GeneMatrix CLIA Certified Lab
Processed in a CLIA-Certified, CE-IVD Certified Lab

Your sample is analyzed using next-generation sequencing (NGS) technology — the same technology used by top hospitals and research institutions. Every result is reviewed by board-certified geneticists before delivery.

CLIA Certified
CE-IVD
HIPAA
GDPR

Real People. Real Discoveries.

What GeneCore customers found out — and what they did about it.

Sarah M.
Sarah M., 44
Chicago, IL
MTHFR C677T variant detected

“I'd struggled with fatigue and brain fog for years. My GeneCore results showed I have a MTHFR variant that blocks folic acid absorption. Switching to methylfolate supplements changed my life within 6 weeks.”

David K.
David K., 52
Houston, TX
APOE ε3/ε4 variant identified

“Finding out I carry an APOE4 variant wasn't scary — it was empowering. I completely changed my diet, started exercising daily, and now my cardiologist is impressed with my numbers at 52.”

Jennifer R.
Jennifer R., 38
Denver, CO
CYP1A2 slow metabolizer found

“I was drinking 4 cups of coffee a day wondering why I couldn't sleep. Turns out I'm a slow caffeine metabolizer. Cut to 1 cup before noon — I sleep 8 hours now and feel incredible.”

10,000+
Reports Delivered
4.9/5
Average Rating
94%
Found Actionable Insights
GeneCore genetic health report
Your 45+ Page Report
Written in plain English. Reviewed by geneticists.
What\'s In Your Report

A 45-Page Guide Written For You

No confusing lab codes. No unexplained numbers. Every page tells you what was found, what it means in everyday language, and exactly what you should do next.

6 Category Risk Summaries
Each health area gets a clear overall risk rating — Low, Moderate, or High — with a plain-English explanation.
Gene-by-Gene Breakdown
Every significant variant explained: what gene, what variant, what it means, and the science behind it.
28+ Actionable Recommendations
Specific steps — supplements to take, foods to avoid, doctors to see, lifestyle changes that match your DNA.
Medication Compatibility Guide
Which common medications your body processes differently — critical to share with your doctor.
Your Personalized Nutrition Plan
Exact macronutrient ratios and food recommendations based on your metabolic gene profile.
Monitoring Checklist
A personalized schedule of which tests and screenings to get, and when, based on your risks.
Included with Essential — $69/mo

Get GeneCore with Essential Plan

GeneCore is included in your Essential Plan subscription — along with 10 other genetic tests. No per-test fees. No surprises.

All 11 genetic tests included
AI-powered analysis & insights
HIPAA-secure patient portal
Physician-ready PDF reports
Free DNA kit shipping
Genetic counselor consultations
Subscribe & Get GeneCore — $69/mo

The Cost Comparison

GeneCore individually

One-time purchase

$599

Essential Plan — all 11 tests

Monthly subscription

$69/mo

This test individually: $599. With your subscription: included at $69/mo along with 10 other tests.

Compare all 11 tests
Also Included in Your Essential Plan

GeneCore is just the beginning

Your subscription unlocks all 11 tests. Here are a few more you get at no extra cost:

GeneCancer

108-gene hereditary cancer panel — BRCA1/2, Lynch syndrome, and more.

Explore GeneCancer

GenePGx

Pharmacogenomics — optimize 700+ medications for your unique DNA.

Explore GenePGx

GeneDiet

Nutrigenomics — personalized nutrition and metabolism insights.

Explore GeneDiet
David K.
“Finding out I carry an APOE4 variant wasn't scary — it was empowering. I completely changed my diet, started exercising daily, and now my cardiologist is impressed with my numbers at 52. GeneCore gave me the roadmap I needed.”

David K.

Houston, TX

APOE ε3/ε4 variant identified

Clinical-Grade Quality You Can Trust

What's Inside the GeneCore Test

The same laboratory quality hospitals use — made simple, accessible, and actionable for you.

Test at a Glance

130+ Genes
Comprehensive panel coverage
5–7 business days
From lab to your inbox
Buccal swab (at-home) or saliva collection kit
Simple at-home collection
Next-generation sequencing (NGS) with polygenic risk scoring
CAP-validated accuracy
CLIA, CAP, CE-IVD
Fully certified laboratory
Insurance Billing Codes
814798143081435

These codes help your insurance process reimbursement. Coverage depends on your plan — we help verify.

Insurance & Coverage

Coverage varies by plan
May not need prior approval
Typical requirements:
  • Preventive wellness testing is typically not covered by insurance
  • HSA/FSA eligible for health optimization purposes
  • Self-pay with transparent pricing available
Check My Coverage

The Genes We Test (130+)

APOE
19q13.32
MTHFR
1p36.22
FTO
16q12.2
ACE
17q23.3
AGT
1q42-q43
CETP
16q22.1
HLA-B
6p21.3
IL6
7p15.3
TNF
6p21.33
GSTM1
1p13.3
GSTT1
22q11.23
NAT2
8p22
VDR
12q13.11
LRP5
11q13.2
BDNF
11p14.1
COMT
22q11.21

Is This Test Right for You?

  • 1
    Individuals seeking comprehensive preventive health insights through genetic testing
  • 2
    Patients with family history of cardiovascular disease, diabetes, or cognitive decline
  • 3
    Wellness-focused individuals wanting personalized lifestyle optimization
  • 4
    Athletes and fitness enthusiasts seeking performance and recovery optimization
  • 5
    People planning major dietary, exercise, or supplement regimen changes
  • 6
    Anyone wanting a single comprehensive genetic health baseline

What Your Report Includes

Cardiovascular risk profile — 25+ genes including APOE, ACE, AGT
Metabolic function analysis — 30+ genes including FTO, MC4R, TCF7L2
Immune system genetics — 20+ genes including HLA, IL6, TNF
Detoxification capacity — 18+ genes including GSTM1, GSTT1, NAT2
Bone health assessment — 15+ genes including VDR, LRP5, COL1A1
Cognitive function screening — 22+ genes including BDNF, APOE, COMT
Personalized nutrition, supplement, and exercise recommendations
Quarterly report updates as new research emerges

How to Get Started

Order Kit

Select your plan. Kit ships free within 24 hours.

Collect DNA

Quick cheek swab at home — under 2 minutes.

Lab Analysis

130+ genes sequenced across 6 health categories.

Your Report

45-page personalized health roadmap in plain English.

Order as a ProviderOrder as a PatientPreview Report
Real Sample Data

Explore a Real GeneCore Report

Click through each category to see exactly what your results will look like — real genes, real findings, real recommendations.

Report ID: GC-2024-78392

Sample Report — For Demonstration Purposes Only

Report Date
2024-01-29
Sample Collected
2024-01-15
Lab ID
14D2276402
NPI
1225729312
Ethnicity
European
134
Genes Analyzed
47
Variants Detected
3
High Risk
12
Moderate Risk
28
Actionable Insights

Cardiovascular Health

Overall Risk:
Moderate
APOE
Variant: ε3/ε4 • rs429358 • Genotype: C/T
Moderate Risk

Increased risk for cardiovascular disease and Alzheimer's disease

Recommendation
Regular cardiovascular monitoring, Mediterranean diet, omega-3 supplementation
MTHFR
Variant: C677T • rs1801133 • Genotype: C/T
Moderate Risk

Reduced enzyme activity affecting homocysteine metabolism

Recommendation
Folate supplementation (methylfolate form), B-vitamin complex
ACE
Variant: I/D • rs4340 • Genotype: I/D
Normal

Balanced ACE enzyme activity

Recommendation
Standard cardiovascular health practices

Medication Compatibility

Warfarin
CYP2C9, VKORC1
May require lower dose - consult physician
Clopidogrel
CYP2C19
Normal response expected
Statins
SLCO1B1
Standard dosing appropriate

Your Nutrition Blueprint

35-40%
Carbs
30-35%
Protein
25-30%
Fats
Increase omega-3 fatty acids (2-3g EPA/DHA daily)
Methylfolate supplementation (800-1000 mcg daily)
Limit caffeine to <200mg per day

See the Full 45-Page Report

Download the complete sample including all 6 categories, medication compatibility, nutrition plan, exercise guide, and monitoring checklist.

Expand Your Genetic Insights

Pair GeneCore with these specialized tests for even deeper answers.

GeneCancer

108+ hereditary cancer genes including BRCA1/2, Lynch syndrome, TP53 and more.

Explore cancer screening

GenePGx

Pharmacogenomics testing — find out how your body processes 700+ medications.

View medication genetics

GeneDiet

Deep nutrition DNA panel — your genetic response to foods, vitamins, and diets.

Discover nutrition genetics
Shop All Tests
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Your DNA Has Answers. Are You Ready to Listen?

Join 10,000+ people who found out exactly what their genes say — and took control of their health with real, personalized knowledge.

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