Hereditary Cancer Genetic Testing & Precision Medicine
CLIA-certified AI-powered genetic testing in Chicago, IL.
View Plans Browse Tests BRCA TestingConsumer DNA tests are fun. Clinical-grade DNA tests save lives. See exactly what you get — and what you miss — with each option.
Family history of cancer. Worried about risk. Needs clarity, not more anxiety.
Only checks 3 Ashkenazi BRCA variants. Misses 95% of clinically relevant cancer genes. Gives false reassurance.
Checks 30 genes — better, but still misses PALB2, TP53, CDH1, and 70+ other high-risk genes.
108-gene panel covers every major hereditary cancer syndrome. If there is a genetic risk, Gene Matrix will find it.
Tried 3 antidepressants. None worked. Side effects were brutal.
No pharmacogenomics testing at all. Zero drug-gene interaction data.
Limited PGx panel (14 genes). Does not cover psychiatric medications.
230+ gene PGx panel including CYP2D6, CYP2C19, SLC6A4 — the exact genes that determine antidepressant response.
Wants to build a health plan around their actual biology.
Surface-level wellness traits. Not clinically actionable. No physician integration.
Strong clinical focus but limited to cancer and cardiac. No nutrition, fitness, or longevity genetics.
11 specialized tests covering cancer, medications, nutrition, fitness, mental health, stress, and longevity — all integrated into one subscription.
Consumer-grade lab (not CLIA-certified for clinical use)
CLIA-certified, CAP-accredited
CLIA-certified, CAP-accredited, CE-IVD Certified
CLIA certification is the federal standard for clinical laboratories. Only CLIA-certified labs can provide physician-ready reports and insurance reimbursement.
3 genes — BRCA1, BRCA2 only (Ashkenazi Jewish variants only)
30 genes — BRCA1, BRCA2, Lynch syndrome, ATM, CHEK2
108 genes — BRCA1, BRCA2, PALB2, Lynch syndrome, TP53, CDH1, STK11, PTEN
Gene Matrix screens 3.6x more cancer genes than Color and 36x more than 23andMe. More genes means catching variants that competitors miss entirely.
Not offered
14 genes, limited medication list
230+ genes, 700+ medications, CPIC/DPWG guidelines, antidepressants, opioids, blood thinners, statins, chemotherapy
Pharmacogenomics can prevent life-threatening adverse drug reactions. Gene Matrix covers 50x more drug-gene interactions than Color and is the only option that includes psychiatric medications.
Not offered
Not offered
95+ genes — serotonin, dopamine, GABA pathways; antidepressant response prediction
Mental health genetics is a core specialty at Gene Matrix, helping psychiatrists select the right medication from the first prescription. No competitor offers this.
44 carrier conditions
30 carrier conditions
200+ inherited conditions — Cystic Fibrosis, SMA, Tay-Sachs, Fragile X, sickle cell
For family planning, coverage breadth matters. Gene Matrix screens 4.5x more inherited conditions than 23andMe and 6.7x more than Color.
20+ wellness traits (limited nutritional genes)
Not offered
120+ genes — macronutrient metabolism, food sensitivities, caffeine, lactose, vitamin absorption
Gene Matrix decodes how your body actually processes nutrients — not just surface-level traits. This is critical for athletes, diabetics, and weight management patients.
SNP microarray chip — cheaper but misses structural variants
Next-generation sequencing (NGS) — clinical-grade
Illumina next-generation sequencing (NGS) + MassArray MALDI-TOF — same platforms used in academic medical centers
NGS detects pathogenic variants that SNP chips miss entirely. Gene Matrix combines NGS with MassArray for ultra-precise targeted variant confirmation.
Not clinically validated — results marked "not for medical use"
High accuracy, clinical-grade validation
99.9% analytical accuracy. Validated against Sanger sequencing with 100% concordance per CAP proficiency testing.
CAP proficiency testing is the gold standard for laboratory accuracy. Gene Matrix participates quarterly and publishes concordance data.
Consumer report — not designed for medical decision-making
Physician-ready clinical report
Physician-ready clinical report with actionable recommendations, genetic counselor consultation included
Only physician-ready reports can be used for insurance reimbursement, clinical treatment decisions, and specialist referrals.
Not included — no counseling available
Included with high-risk results only
Included with every test — board-certified genetic counselors via telehealth or in-person (Chicago)
Genetic counseling is essential for understanding hereditary cancer risk and making informed medical decisions. Gene Matrix includes it for every patient.
$199–$499 one-time per test — no updates, no reinterpretation
$249–$799 one-time per test — no subscription option
Subscription from $69/month — access to 11 tests, quarterly AI reinterpretation, unlimited updates
As science advances, new variants are discovered. A subscription ensures your results stay current. One-time tests are frozen in time.
Not HSA/FSA eligible. No CPT codes. Not insurance-reimbursable.
HSA/FSA eligible for some tests. Insurance support available.
HSA/FSA eligible. CPT codes provided (81432, 81433, 81479). Insurance pre-verification support.
Clinical-grade testing with proper CPT coding can be reimbursed by insurance. Consumer tests cannot.
3–5 weeks
2–3 weeks
5–7 days (72 hours for Premium subscribers)
When cancer risk or medication safety is on the line, every day matters. Gene Matrix delivers results up to 4x faster.
Has sold de-identified data to pharmaceutical companies
HIPAA compliant, no data sales
256-bit encryption, HIPAA + GDPR compliant, zero data sales, patient-controlled deletion
Gene Matrix has never and will never sell patient data. Your genetic information is yours alone.
No reinterpretation — static results from test date
No reinterpretation — static results from test date
Quarterly AI updates re-analyze your raw data against new research — no re-testing needed
Genetic science evolves daily. Gene Matrix is the only provider that automatically updates your risk profile as new variants are discovered.
23andMe is an excellent ancestry and trait discovery tool. Color is a solid clinical cancer screening option. But if you want the most comprehensive, clinically actionable genetic testing available — covering cancer risk, medication safety, mental health, nutrition, fitness, and longevity in one integrated platform — Gene Matrix is the only choice built for people who take their health seriously.
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