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A man at a kitchen counter arranging a weekly pill organizer, a glass of water beside him.

One saliva sample. Checks selected known variants in 15 genes, plus CYP2D6 copy number, by genotyping. One plain report on everyday, pain and mental-health medicines, plus a supplement view, to share with every prescriber and pharmacist you see.

$399self-pay price

One price, paid when you order. We don’t send a claim to your health insurance.

Want to use insurance? Insurance billing is coming soon.

Buy GenePGxSee all tests

Have Medicare, Medicaid or other government coverage? Please contact us before you order.

GenePGx is for adults 18 and older.

The first year of GeneMatrix+ is included when you turn on automatic renewal at checkout. After that it’s $99 a year until you cancel. Renewal is charged to your payment method each year. Leave automatic renewal off and you get the test alone, without a GeneMatrix+ year. Cancel anytime online, or by writing to info@genematrix.io. Your reports stay yours.

  • Genotyped in our own CLIA-certified lab (New York orders excepted)
  • Your genetic data is never sold, and never shared for marketing or research
  • Reports are yours to keep
  • Full refund within 30 days of ordering, as long as your results haven’t been delivered.

Medication Check

Use its generic name. We’ll show whether published CPIC guidance links it to a gene.

Or try one

Pharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

This shows whether published guidance links a medicine to a gene. It does not show whether GenePGx tests that gene.

What’s inside

What used to be three separate tests now sits in one report. The same sample reads the genes behind all four views, and each sets out its medicines by type, in plain words.

  1. Everyday medicines

    Medicines many people take, for the heart and blood pressure, cholesterol, stomach acid and more. How you are likely to process the ones with published guidance.

    Genes behind this view: CYP2C19 · CYP2C9 · VKORC1 · SLCO1B1

    It answersAm I likely to process these at a typical rate, more slowly or more quickly?

  2. Pain medicines

    Medicines used for pain, including some prescribed around an operation or dental work. Written so your surgeon, anesthesiologist or dentist can read it too. It doesn’t test RYR1 or CACNA1S, the genes CPIC’s guidance on some anesthetics uses.

    Genes behind this view: CYP2D6 · CYP2C9

    It answersWhat is worth raising before someone prescribes for my pain?

  3. Mental-health medicines

    Medicines used for depression, anxiety and other conditions. A plain summary to read first, then the detail to go through with your prescriber.

    Genes behind this view: CYP2D6 · CYP2C19 · CYP2B6

    It answersWhat can I bring to my prescriber about how I process these medicines?

  4. Supplements

    A separate set of variants, run alongside the medicine panel, studied in how the body handles some vitamins and supplements. For your information: it does not measure your levels or tell you what to take.

    It answersWhich vitamin and supplement traits do I carry, and what is each linked to?

    The supplement section is never billed to insurance.

Pharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

What you’ll learn

A medicine and a geneA capsule joined by a drawn line to one marked position on a gene.

How you are likely to process medicines that have published pharmacogenomic guidance.

A glass of water, a closed weekly pill organizer, an empty blister pack and a small empty bowl on a table.

  • How you process medicines

    Gene by gene, whether you are likely to process the medicines it affects at a typical rate, more slowly or more quickly.

  • Where guidance applies

    Which of your results are addressed by published gene–drug guidance, and which are not yet.

  • What each result means

    A plain-language summary first, with your genotype and the clinical detail underneath for your prescriber.

  • What to share, and with whom

    Which results are worth raising with your prescriber, your pharmacist and anyone planning an operation or dental work with you.

  • A result for later, too

    Your genes don’t change, so the same result can inform medicines you haven’t been prescribed yet.

Your report

Each result names the gene, your genotype and the metabolizer status it corresponds to, in plain words first. Under it sits the clinical detail a prescriber or pharmacist reads, alongside everything else they know about you. It informs their decision; it does not make it.

See a full sample report

Illustrative, not a real person’s result

GenePGx · Medication response

Illustrative example

Three results
shown
  • CYP2C19Intermediate metabolizer
  • CYP2D6Normal metabolizer
  • SLCO1B1Decreased function
GeneResultPhenotype
CYP2C19*1/*2Intermediate metabolizerGuidance exists for: clopidogrel, citalopram, sertraline
CYP2D6*1/*1Normal metabolizerGuidance exists for: codeine, tramadol, ondansetron
SLCO1B1rs4149056 T/CDecreased functionGuidance exists for: simvastatin, atorvastatin
Pharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

Ways to buy

One self-pay price, paid once when you order. Results are usually ready 5 to 7 business days after the lab receives your activated sample (10 to 14 business days during holiday weeks).

GenePGx, self-pay

$399 self-pay price

Self-pay price, paid once

  • Saliva, from a gentle swab along your gums at home
  • One report with everyday, pain and mental-health medicine views, plus a supplement view
Buy GenePGx

One price, paid when you order. We don’t send a claim to your health insurance.

Add to cart: GenePGx

The first year of GeneMatrix+ is included when you turn on automatic renewal at checkout. After that it’s $99 a year until you cancel. Renewal is charged to your payment method each year. Leave automatic renewal off and you get the test alone, without a GeneMatrix+ year. Cancel anytime online, or by writing to info@genematrix.io. Your reports stay yours.

Have Medicare, Medicaid or other government coverage? Please contact us before you order.

Insurance billing

Coming soon

Want to use insurance? Insurance billing is coming soon.

The supplement section is never billed to insurance.

How insurance billing will work

  • The guaranteeFull refund within 30 days of ordering, as long as your results haven’t been delivered. Once your results are delivered, the guarantee no longer applies.

  • Your dataWe never sell your genetic data, and we never share it for marketing or research. It goes only to those who complete your order: the laboratory that runs your tests; for an order shipped to New York, the physician or reference laboratory that completes it; and service providers under contract that store your data or prepare your report for us, including Labrynix and SignalPGx, the laboratory-information and reporting software we use. Once we can bill health plans, and only if you choose to bill our pharmacogenomics (PGx) test to yours, your health plan receives what it needs to process that claim, and for no other purpose. Nutrigenomics and oral microbe results never go to a health plan. That holds while GeneMatrix+ is active and after it ends.

  • Cancel anytimeCancel anytime online, or by writing to info@genematrix.io. Your reports stay yours; re-reads stop when GeneMatrix+ ends.

Free shipping within the US

Comparing prices? What PGx testing costs

What is GenePGx?

GenePGx is GeneMatrix’s at-home pharmacogenomic (PGx) test. From one saliva sample you collect at home, our own CLIA-certified laboratory in Chicago (New York orders excepted) checks selected known variants in genes that affect how your body processes some medicines, by genotyping.

Your report shows how you are likely to process medicines with published guidance for those genes, written to be read with your prescriber and pharmacist. GenePGx is $399, paid once when you order. Results are usually ready 5 to 7 business days after the lab receives your activated sample (10 to 14 business days during holiday weeks).

It can’t tell you whether a medicine will work for you, and it isn’t dosing advice.

Pharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

Is there a genetic test for pain medicines?

Yes, as one part of a wider report. GenePGx’s pain view shows how your genes may affect the way your body processes some pain relievers, in words your prescriber, surgeon or dentist can read too. It draws on genes the panel tests, including CYP2D6 and CYP2C9.

It can’t say which medicine will work for you. Keep taking your medicines as prescribed, and bring the report to the person who prescribes them.

Pharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

Which genes does GenePGx check?

Checks selected known variants in 15 genes, plus CYP2D6 copy number, by genotyping.

It tests genes named in CPIC prescribing guidelines for 56 medicines (checked September 29, 2026).

Pharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

A man in a navy sweater listening across a desk to a clinician in a light-blue shirt, a bound report with blank pages open between them.

Who it’s for

It’s for you if

  • You take several medicines, or expect to, and want to know how your genes may affect them.
  • A medicine has not suited you in the past and you want to understand whether genetics plays a part.
  • You have an operation or dental work ahead, or live with long-term pain, and want your result ready for whoever prescribes.
  • You want a result on file that any prescriber can consider in the future.

It isn’t for

  • It does not tell you what to take or how much. Those decisions stay with your prescriber.
  • It is not a reason to act on your own. Bring any result to the clinician who manages your medicines.
  • It is not a diagnosis, and it cannot tell you whether a medicine suits you.
  • The supplement view does not measure your vitamin levels. Only a blood test does.

Genes

The medicine panel reads a set list of known variants in these genes. A separate supplement set runs alongside it.

  • CYP2B6
  • CYP2C19
  • CYP2C9
  • CYP2D6
  • CYP3A4
  • CYP3A5
  • CYP4F2
  • DPYD
  • HLA-A
  • HLA-B
  • NUDT15
  • SLCO1B1
  • TPMT
  • UGT1A1
  • VKORC1
CYP2D6 copies
It counts copies of the CYP2D6 gene, so a missing copy or extra copies show in your result.
DPYD
It checks DPYD, a gene named in CPIC guidance for some chemotherapy medicines.
HLA
Checks four specific HLA types linked to serious medicine reactions. It does not identify your full HLA type. The four: HLA-A*31:01, HLA-B*15:02, HLA-B*57:01 and HLA-B*58:01.
Guidelines
It tests genes named in CPIC prescribing guidelines for 56 medicines (checked September 29, 2026).
Limits
It checks a set list of known variants in these genes and counts copies of the CYP2D6 gene. It does not read whole genes, so it can miss rare or new variants, and a result with no variant found does not rule out a change in how you process a medicine.

Pharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

An automated liquid-handling workstation with its door open, tip boxes and sample plates on its deck.
Illustrative image, not our laboratory.

Our lab

GeneMatrix runs its own CLIA-certified laboratory in Chicago, and every order is tested there except those shipped to New York. These are the people and credentials behind your results.

Laboratory director
Dr. Shawn Desai, Ph.D., J.D., N.R.C.C.
CLIA certificate
14D2276402
Address
1375 W Fulton St, Suite 545, Chicago, IL 60607
See the certificate and the director

How it works

How it works, step by step
  1. Hands opening the GeneMatrix kit box.

    Your kit arrives

    Order online and the kit comes by mail, straight from the lab, with the swab, its tube and everything you need to use it.

  2. A hand capping the sample collection tube.

    Collect at home

    Wait 30 minutes after eating or drinking, then rub the soft swab along your lower gums, 10 times on each side. Seal it in its tube and send it back as the kit explains.

  3. Genotyped in our lab

    Your saliva sample is genotyped in our own CLIA-certified lab in Chicago.

    Orders shipped to New York are completed through a physician order or a reference laboratory permitted in New York.

  4. An older man reading on his phone in a linen armchair by a tall window, seen from behind.

    Your report

    When your results are ready we email you (the email never names your test) with the lab’s secure link to your report, which asks for the tested person’s details before it opens. It is in plain words, to read in your own time.

What’s in your kit

  • The swab and its tubeA soft sponge swab on a cap, and a tube with a little liquid that keeps your sample stable in the post.
  • Step-by-step instructionsPrinted, in plain words, from the wait before you start to the post box.
  • An activation cardYour kit ID, with a QR code and a barcode. Scan it to activate your kit before you mail it.
  • A specimen bagA sealable bag with an absorbent pad inside, which the postal rules ask for.
  • A sealA sticker across the box flap, so it arrives as you closed it.
  • A prepaid return boxThe return box and a prepaid USPS return label. Postage is paid.

Related tests

GeneCancer $399 Selected variants only, by genotyping. Not a full-gene test. Genotyping of selected inherited variants linked to higher cancer risk
Medication Check Tool Type a medicine to see whether published guidance links it to a gene.

Further reading

More on pharmacogenomics

Questions

Will this tell me which medicine to take?

No. It says how you are likely to process medicines that have published guidance. Choosing a medicine, and how much of it, stays with your prescriber.

Which medicines does it cover?

Medicines with published pharmacogenomic guidance for the genes on this panel, set out in everyday, pain and mental-health views. Checks selected known variants in 15 genes, plus CYP2D6 copy number, by genotyping. It tests genes named in CPIC prescribing guidelines for 56 medicines (checked September 29, 2026). Some of those guidelines also use genes the panel does not test, so a result informs part of the picture for them. The Medication Check on this page shows whether published guidance links a medicine to a gene; it does not show whether this panel tests that gene.

What happened to GenePain, GeneMind and GenePharma?

They are now part of GenePGx. One report covers everyday, pain and mental-health medicines, with a supplement view, from one saliva sample.

Can I use my health insurance?

Not yet. Insurance billing is coming soon. Today GenePGx has one price: $399 self-pay price. One price, paid when you order. We don’t send a claim to your health insurance.

I have Medicare or Medicaid. Can I order?

Have Medicare, Medicaid or other government coverage? Please contact us before you order.

I have an operation coming up. When should I test?

Well before the date, so the report is ready to share with your surgeon, anesthesiologist or dentist. It doesn’t test RYR1 or CACNA1S, the genes CPIC’s guidance on some anesthetics uses. Your genes don’t change, so a result on file now can inform a medicine offered later.

Should I share the report with my pharmacist?

Yes. Pharmacists and prescribers can read the clinical detail under each plain-language result.

Do I need a doctor’s order?

You can order online; self-pay orders don’t need a doctor’s order. If insurance billing opens, your own clinician will need to order the test. Orders shipped to New York are completed through a physician order or a reference laboratory permitted in New York.

Buy GenePGx, $399Compare ways to buy

One price, paid when you order. We don’t send a claim to your health insurance.

Limits

Your saliva sample is genotyped on the Agena Bioscience MassARRAY® System in our own CLIA-certified lab in Chicago (New York orders excepted). Genotyping reads selected positions in the genes on this panel; it does not read every position in those genes, or your whole genome.

MassARRAY is a registered trademark of Agena Bioscience, Inc.

How we know: How does pharmacogenomics work? A plain-English guide

  1. Genes are one part of how a medicine acts. Age, other medicines, diet, and kidney and liver function also matter, and a result does not account for them.
  2. Guidance exists for some gene–drug pairs and not others. A medicine without published guidance is not covered by this report.
  3. The supplement view describes traits studied across groups of people. It does not measure your levels, and it does not tell you what to take.
  4. The report reflects the guidance published when it was written, and guidance can change after that. With GeneMatrix+, your reports are re-read automatically whenever the evidence from our sources is updated.

Please read

LabOur genetic tests are laboratory-developed tests performed in our own CLIA-certified laboratory. New York is the exception: orders shipped there are completed through a physician order or a reference laboratory permitted in New York. Our genetic tests have not been cleared or approved by the FDA. Results describe inherited traits and risks and are meant to inform decisions you make with your clinician. They are not a diagnosis.

PGxPharmacogenomic results describe how your body is likely to process certain medicines. They do not tell you whether a medicine will work for you, and they are not dosing instructions. Never start, stop or change a medication because of a genetic result. Bring it to the prescriber who manages your medicines.

WellnessOur nutrition, supplement, athletic and wellbeing reports are for general wellness and information. The evidence behind these associations is less established than for our clinical panels, and these reports are not intended to diagnose, treat, cure or prevent any disease.

CancerTesting for inherited cancer risk is a screening test, not a diagnosis. A result with no variant found does not mean you will not develop cancer, and finding a variant does not mean you will. Talk to your doctor or a genetic counselor before making any decision about screening, medication or surgery.

Who writes our guides, where their facts come from and how to ask for a correction: our editorial policy.

A frosted weekly pill organizer with blank lids beside the sample collection tube on pale stone.

Have your result ready before the next prescription.

$399self-pay price

One price, paid when you order. We don’t send a claim to your health insurance.

Want to use insurance? Insurance billing is coming soon.

Buy GenePGxSee all tests

Have Medicare, Medicaid or other government coverage? Please contact us before you order.

GenePGx is for adults 18 and older.

The first year of GeneMatrix+ is included when you turn on automatic renewal at checkout. After that it’s $99 a year until you cancel. Renewal is charged to your payment method each year. Leave automatic renewal off and you get the test alone, without a GeneMatrix+ year. Cancel anytime online, or by writing to info@genematrix.io. Your reports stay yours.