Science
This page sets out our method, what a report can and can’t tell you, and where its limits sit.
The method
Genotyping reads a defined set of positions across the genes on your panel: places research has already linked to a variant. It is not a reading of your whole genome, and a position your panel does not read stays unread.
GenePGx is genotyped on the Agena Bioscience MassARRAY® System. MassARRAY is a registered trademark of Agena Bioscience, Inc.
Performed in our own CLIA-certified laboratory in Chicago. Orders shipped to New York are completed through a physician order or a reference laboratory permitted in New York.
What it can and can’t tell you
Can
Read the positions on your panel
Each panel checks a defined list of variants. A result tells you what was found at those specific positions.
Point to published guidance
Wherever your panel carries a variant with guidance from published guidance and evidence sources, the report says so.
Give you something to bring to your clinician
Each report sets out what was found and what it means, for a conversation with the clinician who knows your history.
Can’t
Diagnose a condition
A result is information, not a diagnosis. It informs a decision you make with your clinician; it does not make one for you.
See beyond the panel
The panel reads selected positions in the genes it lists. A variant at a position it does not read, or in a gene that is not on the panel, will not be found.
Tell you what will happen to you
The associations come from population studies. They describe tendencies across groups, not how any one person responds. A result is not a diagnosis.
The re-read pipeline
Your genome doesn’t change. What’s known about it does. Here is how an update reaches you.
Published guidance and evidence sources
Tracked as they change.
Your report is re-read
With GeneMatrix+, automatically whenever the evidence from our sources is updated.
The updated report through the lab’s secure link, which we email you
01
The evidence changes.
We track published guidance and evidence sources as they change.
02
Your report is re-read.
With GeneMatrix+, your genetic reports are re-read automatically whenever the evidence from our sources is updated.
03
Your updated report is ready.
Once it’s re-read, the updated report is sent to you through the lab’s secure link, which we email you.
04
Re-reads come with GeneMatrix+.
Re-reads are part of GeneMatrix+, for as long as it stays active. The first year of GeneMatrix+ is included when you turn on automatic renewal at checkout.
Evidence and review
We track published guidance and evidence sources. With GeneMatrix+, reports are re-read automatically whenever the evidence from our sources is updated.
Results are released under the responsibility of our laboratory director.
Validation and accuracy
We publish only what is confirmed. The rest stays off this page until it is.
- Certification
- CLIA 14D2276402
- Genotyped
- Performed in our own CLIA-certified laboratory in Chicago. Orders shipped to New York are completed through a physician order or a reference laboratory permitted in New York.
Limitations
- A result with no variant found means none of the panel’s own variants were found, not that no risk exists.
- A finding reflects what the evidence showed when your report was last read. GeneMatrix+ catches what changes after that.
- A report is not a substitute for the judgment of your doctor or a genetic counselor.
Further reading
- Genotyping vs sequencing: what each finds, and what our lab usesGenotyping checks known DNA positions chosen in advance; reading whole genes can also find rare and new variants.Updated October 2, 2026
- How much does genetic testing cost? What you pay at GeneMatrixEvery GeneMatrix test has one published self-pay price, paid when you order.Updated October 2, 2026
- DNA health test: what your genes can and can’t tell youWhat a DNA health test can and can’t tell you, and which kind of test answers which question.Updated October 1, 2026
- GeneMatrix vs 23andMe: which DNA test fits what you want to know?Both use genotyping in CLIA-certified labs; the difference is what each test is for.Updated October 1, 2026
- For healthcare providers: reading a GeneMatrix reportFor clinicians: what our genetic reports cover, their limits, and how to reach the laboratory.Updated September 30, 2026
Our promises
The guarantee
Full refund within 30 days of ordering, as long as your results haven’t been delivered. Once your results are delivered, the guarantee no longer applies.
Cancel anytime
Cancel anytime online, or by writing to info@genematrix.io. Your reports stay yours; re-reads stop when GeneMatrix+ ends.
Your data
We never sell your genetic data, and we never share it for marketing or research. It goes only to those who complete your order: the laboratory that runs your tests; for an order shipped to New York, the physician or reference laboratory that completes it; and service providers under contract that store your data or prepare your report for us, including Labrynix and SignalPGx, the laboratory-information and reporting software we use. Once we can bill health plans, and only if you choose to bill our pharmacogenomics (PGx) test to yours, your health plan receives what it needs to process that claim, and for no other purpose. Nutrigenomics and oral microbe results never go to a health plan. That holds while GeneMatrix+ is active and after it ends.
Read once. Kept current.
Full refund within 30 days of ordering, as long as your results haven’t been delivered.
Please read
Please read
LabOur genetic tests are laboratory-developed tests performed in our own CLIA-certified laboratory. New York is the exception: orders shipped there are completed through a physician order or a reference laboratory permitted in New York. Our genetic tests have not been cleared or approved by the FDA. Results describe inherited traits and risks and are meant to inform decisions you make with your clinician. They are not a diagnosis.
WellnessOur nutrition, supplement, athletic and wellbeing reports are for general wellness and information. The evidence behind these associations is less established than for our clinical panels, and these reports are not intended to diagnose, treat, cure or prevent any disease.